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Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats
Joint Authors
Lu, Su-Hong
Guan, Jian-Hua
Huang, Yan-Li
Pan, Yu-Wei
Yang, Wei
Lan, Hai
Huang, Si
Hu, Jing
Zhao, Guo-Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The research tries to establish Wistar rat’s model of atherosclerosis for evaluating the antiatherosclerotic effect of hederagenin and exploring its antiatherosclerosis-related mechanisms.
The statistical data have shown that hederagenin exhibits multiple pharmacological activities in the treatment of hyperlipidemia, antiplatelet aggregation, liver protection, and anti-inflammation, indicating that hederagenin may exert a protective effect on vascular walls by improving lipid metabolism disorders and lipid deposition.
The results show that hederagenin can correct the imbalance of endothelial function by inhibiting the release of large amounts of iNOS and increasing eNOS contents and inhibits the IKKβ/NF-κB signaling pathway to reduce the release of IL-6, IFN-γ, TNF-α, and other inflammatory factors.
The experimental results indicated that hederagenin can inhibit or ameliorate the pathological changes associated with AS, displaying an excellent preventive function against AS.
American Psychological Association (APA)
Lu, Su-Hong& Guan, Jian-Hua& Huang, Yan-Li& Pan, Yu-Wei& Yang, Wei & Lan, Hai…[et al.]. 2015. Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061516
Modern Language Association (MLA)
Lu, Su-Hong…[et al.]. Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061516
American Medical Association (AMA)
Lu, Su-Hong& Guan, Jian-Hua& Huang, Yan-Li& Pan, Yu-Wei& Yang, Wei & Lan, Hai…[et al.]. Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061516