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Effects of Chung-Pae Inhalation Therapy on a Mouse Model of Chronic Obstructive Pulmonary Disease
Joint Authors
Joo, Myungsoo
Jung, Hee Jae
Kim, Kwan-Il
Lee, Beom-Joon
Choi, Jun-Yong
Hwang, Joon-Ho
Jung, Sung-ki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Chung-pae (CP) inhalation therapy is a method frequently used in Korea to treat lung disease, especially chronic obstructive pulmonary disease (COPD).
This study investigated the effects of CP inhalation on a COPD animal model.
C57BL/6 mice received porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS) alternately three times for 3 weeks to induce COPD.
Then, CP (5 or 20 mg/kg) was administered every 2 h after the final LPS administration.
The effect of CP was evaluated by bronchoalveolar lavage (BAL) fluid analysis, histological analysis of lung tissue, and reverse transcription polymerase chain reaction analysis of mRNA of interleukin- (IL-) 1β, tumor necrosis factor- (TNF-) α, IL-6, and tumor growth factor- (TGF-) β.
Intratracheal CP administration reduced the number of leukocytes and neutrophils in BAL fluid, inhibited the histological appearance of lung damage, and decreased the mRNA levels of the proinflammatory cytokines IL-1β, TNF-α, IL-6, and TGF-β.
Intratracheal CP administration effectively decreased the chronic inflammation and pathological changes in a PPE- and LPS-induced COPD mouse model.
Therefore, we suggest that CP is a promising strategy for COPD.
American Psychological Association (APA)
Hwang, Joon-Ho& Lee, Beom-Joon& Jung, Hee Jae& Kim, Kwan-Il& Choi, Jun-Yong& Joo, Myungsoo…[et al.]. 2015. Effects of Chung-Pae Inhalation Therapy on a Mouse Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061524
Modern Language Association (MLA)
Hwang, Joon-Ho…[et al.]. Effects of Chung-Pae Inhalation Therapy on a Mouse Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1061524
American Medical Association (AMA)
Hwang, Joon-Ho& Lee, Beom-Joon& Jung, Hee Jae& Kim, Kwan-Il& Choi, Jun-Yong& Joo, Myungsoo…[et al.]. Effects of Chung-Pae Inhalation Therapy on a Mouse Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1061524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061524