Total Flavonoids from Clinopodium chinense (Benth.) O. Ktze Protect against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo
Joint Authors
Zhang, Qiang
Chen, Rong Chang
Xu, Xu Dong
Zhi Liu, Xue
Sun, Gui Bo
Zhu, Yin Di
Dong, Xi
Wang, Jian
Zhang, Hai Jing
Sun, Xiao Bo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-16
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Doxorubicin has cardiotoxic effects that limit its clinical benefit in cancer patients.
This study aims to investigate the protective effects of the total flavonoids from Clinopodium chinense (Benth.) O.
Ktze (TFCC) against doxorubicin- (DOX-) induced cardiotoxicity.
Male rats were intraperitoneally injected with a single dose of DOX (3 mg/kg) every 2 days for three injections.
Heart samples were collected 2 weeks after the last DOX dose and then analyzed.
DOX delayed body and heart growth and caused cardiac tissue injury, oxidative stress, apoptotic damage, mitochondrial dysfunction, and Bcl-2 expression disturbance.
Similar experiments in H9C2 cardiomyocytes showed that doxorubicin reduced cell viability, increased ROS generation and DNA fragmentation, disrupted mitochondrial membrane potential, and induced apoptotic cell death.
However, TFCC pretreatment suppressed all of these adverse effects of doxorubicin.
Signal transduction studies indicated that TFCC suppressed DOX-induced overexpression of p53 and phosphorylation of JNK, p38, and ERK.
Studies with LY294002 (a PI3K/AKT inhibitor) demonstrated that the mechanism of TFCC-induced cardioprotection also involves activation of PI3K/AKT.
These findings indicated the potential clinical application of TFCC in preventing DOX-induced cardiac oxidative stress.
American Psychological Association (APA)
Chen, Rong Chang& Xu, Xu Dong& Zhi Liu, Xue& Sun, Gui Bo& Zhu, Yin Di& Dong, Xi…[et al.]. 2015. Total Flavonoids from Clinopodium chinense (Benth.) O. Ktze Protect against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1061539
Modern Language Association (MLA)
Chen, Rong Chang…[et al.]. Total Flavonoids from Clinopodium chinense (Benth.) O. Ktze Protect against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1061539
American Medical Association (AMA)
Chen, Rong Chang& Xu, Xu Dong& Zhi Liu, Xue& Sun, Gui Bo& Zhu, Yin Di& Dong, Xi…[et al.]. Total Flavonoids from Clinopodium chinense (Benth.) O. Ktze Protect against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1061539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061539