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The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue
Joint Authors
Guarner Lans, Verónica
Díaz-Díaz, Eulises
Pérez-Torres, Israel
Peredo-Escárcega, Ana Elena
Ortega-Ocampo, Sergio
Carreón-Torres, Elizabeth
Castrejón-Tellez, Vicente
Rubio-Ruiz, María Esther
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Resveratrol (RSV) and quercetin (QRC) modify energy metabolism and reduce cardiovascular risk factors included in the metabolic syndrome (MetS).
These natural compounds upregulate and activate sirtuins (SIRTs), a family of NAD-dependent histone deacetylases.
We analyzed the effect of two doses of a commercial combination of RSV and QRC on serum fatty acid composition and their regulation of SIRTs 1–3 and PPAR-γ expression in white adipose tissue.
MetS was induced in Wistar rats by adding 30% sucrose to drinking water for five months.
Rats were divided into control and two groups receiving the two different doses of RSV and QRC in drinking water daily for 4 weeks following the 5 months of sucrose treatment.
Commercial kits were used to determine serum parameters and the expressions of SIRTs in WAT were analysed by western blot.
In MetS rats body mass, central adiposity, insulin, triglycerides, non-HDL-C, leptin, adiponectin, monounsaturated fatty acids (MUFAs), and nonesterified fatty acids (NEFAs) were increased, while polyunsaturated fatty acids (PUFAs) and HDL-C were decreased.
SIRT 1 and SIRT 2 were downregulated, while PPAR-γ was increased.
RSV + QRC administration improved the serum health parameters modified by MetS and upregulate SIRT 1 and SIRT 2 expression in white abdominal tissue in MetS animals.
American Psychological Association (APA)
Peredo-Escárcega, Ana Elena& Guarner Lans, Verónica& Pérez-Torres, Israel& Ortega-Ocampo, Sergio& Carreón-Torres, Elizabeth& Castrejón-Tellez, Vicente…[et al.]. 2015. The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061543
Modern Language Association (MLA)
Peredo-Escárcega, Ana Elena…[et al.]. The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1061543
American Medical Association (AMA)
Peredo-Escárcega, Ana Elena& Guarner Lans, Verónica& Pérez-Torres, Israel& Ortega-Ocampo, Sergio& Carreón-Torres, Elizabeth& Castrejón-Tellez, Vicente…[et al.]. The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1061543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061543