Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca
Joint Authors
Ghaddar, Tarek H.
Nasr, Bilal
Fares, Mohamed-Bilal
Ajeeb, Bushra
Nahhas, Rana
Al Aaraj, Lamis
Talhouk, Salma N.
Saliba, Najat A.
Talhouk, Rabih
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A sesquiterpene lactone 1-β,10-Epoxy-6-hydroxy-1,10H-inunolide (K100) was isolated through “bioassay-guided fractionation” from Cota palaestina subsp.
syriaca, an Eastern Mediterranean endemic plant.
K100 inhibited endotoxin- (ET-) induced proinflammatory markers: IL-6, MMP-9, and NO in normal mouse mammary SCp2 Cells.
Molecular docking in silico suggested that K100, having highly analogous structure as parthenolide (PTL), an anticancer compound, could bind PTL target proteins at similar positions and with comparable binding affinities.
Both compounds, K100 and PTL, inhibited the proliferation and prolonged the S-phase of the cell cycle of breast adenocarcinoma MDA-MB-231 cells grown in 2D cultures.
Noncytotoxic concentrations of K100 and PTL decreased the proliferation rate of MDA-MB-231 and shifted their morphology from stellate to spherical colonies in 3D cultures.
This was accompanied with a significant increase in the amount of small colonies and a decrease in the amount of large colonies.
Moreover, K100 and PTL decreased cellular motility and invasiveness of MDA-MB-231 cells.
In summary, these results suggest that K100 exhibits PTL-analogous anti-inflammatory, cytostatic, and antimetastatic effects.
American Psychological Association (APA)
Talhouk, Rabih& Nasr, Bilal& Fares, Mohamed-Bilal& Ajeeb, Bushra& Nahhas, Rana& Al Aaraj, Lamis…[et al.]. 2015. Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061545
Modern Language Association (MLA)
Talhouk, Rabih…[et al.]. Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1061545
American Medical Association (AMA)
Talhouk, Rabih& Nasr, Bilal& Fares, Mohamed-Bilal& Ajeeb, Bushra& Nahhas, Rana& Al Aaraj, Lamis…[et al.]. Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1061545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061545