![](/images/graphics-bg.png)
Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL6 LDLr-Null Mice Undergoing High Fat Diet
Joint Authors
Botelho Lourenço, Emerson Luiz
Gasparotto Junior, Arquimedes
Vieira, Jennifer Alexandra Castanho
Gasparotto, Francielly Mourão
Cardozo Junior, Euclides Lara
Araújo, Valdinei de Oliveira
Pires, Vanessa
Maciel, Aline Antunes
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although Vitex megapotamica (Spreng.) Moldenke is used in Brazilian folk medicine as hypolipidemic drug no study has been conducted to evaluate the effects of this species in an experimental model of atherosclerosis.
So, the aim of this study was to evaluate the possible renoprotective activity of methanolic extract obtained from Vitex megapotamica (MEVM) using C57BL/6 LDLr-null mice submitted to high fat diet (HFD).
MEVM was orally administered at doses of 30, 100, and 300 mg/kg, for three weeks, starting from the 2nd week of HFD.
Systolic blood pressure (SBP) and diuretic activity were measured weekly.
At the end of experiments the serum lipids, atherogenic index serum (AIS), oxidative stress, and markers of renal function were determined.
HFD induced a significant increase in the systolic blood pressure, dyslipidemia, increase in AIS, and lipid peroxidation accompanied by an important reduction in renal function.
Treatment with MEVM was able to prevent increase in SBP, total cholesterol, triglycerides, AIS, urea, and creatinine levels in LDLr-null mice.
These effects were accompanied by a significant reduction in oxidative stress and renal injury.
The data reported here support the potential of Vitex megapotamica as candidate to be an herbal medicine used in cardiovascular or renal diseases.
American Psychological Association (APA)
Araújo, Valdinei de Oliveira& Gasparotto, Francielly Mourão& Pires, Vanessa& Maciel, Aline Antunes& Vieira, Jennifer Alexandra Castanho& Cardozo Junior, Euclides Lara…[et al.]. 2015. Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL6 LDLr-Null Mice Undergoing High Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061547
Modern Language Association (MLA)
Araújo, Valdinei de Oliveira…[et al.]. Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL6 LDLr-Null Mice Undergoing High Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1061547
American Medical Association (AMA)
Araújo, Valdinei de Oliveira& Gasparotto, Francielly Mourão& Pires, Vanessa& Maciel, Aline Antunes& Vieira, Jennifer Alexandra Castanho& Cardozo Junior, Euclides Lara…[et al.]. Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL6 LDLr-Null Mice Undergoing High Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1061547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061547