Effects of Different Local Moxibustion-Like Stimuli at Zusanli (ST36) and Zhongwan (CV12) on Gastric Motility and Its Underlying Receptor Mechanism
Joint Authors
Xin, Juan-Juan
Wang, Xiao-Yu
Shi, Hong
Su, Yang-Shuai
Yang, Zhao-Kun
He, Wei
Jing, Xiang-Hong
Zhu, Bing
Hu, Ling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to explore the “intensity-response” relationship in local moxibustion-like stimuli- (LMS-) modulated gastric motility and its underlying receptor mechanism.
Based on the thermal pain threshold (43°C), 41°C, 43°C, and 45°C LMS were separately applied to ST36 or CV12 for 180 s among ASIC3 knockout (ASIC3−/−) mice, TRPV1 knockout (TRPV1−/−) mice, and their homologous wild-type C57BL/6 mice ( n = 8 in each group).
Gastric motility was continuously measured by an intrapyloric balloon, and the amplitude, integral, and frequency of gastric motility during LMS were compared with those of initial activities.
We found that both 43°C and 45°C LMS at ST36 induced significantly facilitated effect of gastric motility P < 0.05 , while LMS at CV12 induced inhibited effects P < 0.05 .
41°C LMS had no significant impact on gastric motility.
Compared with C57BL/6 mice, the facilitatory effect at ST36 and inhibitive effect of LMS at CV12 were decreased significantly in TRPV1−/− mice ( P < 0.05 ; P < 0.01 ) but not changed markedly in ASIC3−/− mice P > 0.05 .
These results suggest that there existed an “intensity-response” relationship between temperature in LMS and its effects on gastric motility.
TRPV1 receptor played a crucial role in the LMS-modulated gastric motility.
American Psychological Association (APA)
Su, Yang-Shuai& Xin, Juan-Juan& Yang, Zhao-Kun& He, Wei& Shi, Hong& Wang, Xiao-Yu…[et al.]. 2015. Effects of Different Local Moxibustion-Like Stimuli at Zusanli (ST36) and Zhongwan (CV12) on Gastric Motility and Its Underlying Receptor Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061558
Modern Language Association (MLA)
Su, Yang-Shuai…[et al.]. Effects of Different Local Moxibustion-Like Stimuli at Zusanli (ST36) and Zhongwan (CV12) on Gastric Motility and Its Underlying Receptor Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1061558
American Medical Association (AMA)
Su, Yang-Shuai& Xin, Juan-Juan& Yang, Zhao-Kun& He, Wei& Shi, Hong& Wang, Xiao-Yu…[et al.]. Effects of Different Local Moxibustion-Like Stimuli at Zusanli (ST36) and Zhongwan (CV12) on Gastric Motility and Its Underlying Receptor Mechanism. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1061558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061558