![](/images/graphics-bg.png)
Potential Mechanisms Responsible for the Antinephrolithic Effects of an Aqueous Extract of Fructus Aurantii
Joint Authors
Li, Xiaoran
Liang, Qiang
Sun, Yunji
Diao, Long
Qin, Ze
Wang, Wei
Lu, Jianzhong
Fu, Shengjun
Ma, Baoliang
Yue, Zhongjin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The potential effects of Fa extract on the prevention and treatment of CaOx nephrolithiasis were analyzed in an ethylene glycol- (EG-) induced CaOx crystallization model in rats and an in vitro assay.
Multiple biochemical variables were measured in the urine and kidney.
Kidney sections were subjected to histopathological and immunohistochemical analyses.
Urolithiasis-related osteopontin (OPN) was evaluated by Western blotting.
The in vitro assay revealed the significant inhibition of crystal formation ( 3.50 ± 1.43 ) and dilution of formed crystals ( 12.20 ± 3.35 ) in the group treated with 1 mg/mL Fa extract compared with the control group ( 52.30 ± 4.71 and 53.00 ± 4.54 , resp.) ( p < 0.05 ).
The in vivo experiments showed that prophylactic treatment with Fa aqueous extract significantly prevented EG-induced renal crystallization and pathological alterations compared with nephrolithic rats ( p < 0.05 ).
Significantly lower levels of oxidative stress, oxalate, and OPN expression as well as increased citrate and urine output levels were observed in both the low- and high-dose prophylactic groups ( p < 0.05 ).
However, in the low- and high-dose therapeutic groups, none of these indexes were significantly improved ( p > 0.05 ) except for urinary oxalate in the high-dose therapeutic groups ( p < 0.05 ).
Fa extract prevented CaOx crystallization and promoted crystal dissolution in vitro.
Additionally, it was efficacious in preventing the formation of CaOx nephrolithiasis in rats.
American Psychological Association (APA)
Li, Xiaoran& Liang, Qiang& Sun, Yunji& Diao, Long& Qin, Ze& Wang, Wei…[et al.]. 2015. Potential Mechanisms Responsible for the Antinephrolithic Effects of an Aqueous Extract of Fructus Aurantii. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061561
Modern Language Association (MLA)
Li, Xiaoran…[et al.]. Potential Mechanisms Responsible for the Antinephrolithic Effects of an Aqueous Extract of Fructus Aurantii. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1061561
American Medical Association (AMA)
Li, Xiaoran& Liang, Qiang& Sun, Yunji& Diao, Long& Qin, Ze& Wang, Wei…[et al.]. Potential Mechanisms Responsible for the Antinephrolithic Effects of an Aqueous Extract of Fructus Aurantii. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1061561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061561