In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia
Joint Authors
Sinniah, Uma Rani
Swamy, Mallappa Kumara
Akhtar, Mohd. Sayeed
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated the effect of different solvents (ethyl acetate, methanol, acetone, and chloroform) on the extraction of phytoconstituents from Lantana camara leaves and their antioxidant and antibacterial activities.
Further, GC-MS analysis was carried out to identify the bioactive chemical constituents occurring in the active extract.
The results revealed the presence of various phytocompounds in the extracts.
The methanol solvent recovered higher extractable compounds (14.4% of yield) and contained the highest phenolic (92.8 mg GAE/g) and flavonoid (26.5 mg RE/g) content.
DPPH radical scavenging assay showed the IC50 value of 165, 200, 245, and 440 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively.
The hydroxyl scavenging activity test showed the IC50 value of 110, 240, 300, and 510 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively.
Gram negative bacterial pathogens (E.
coli and K.
pneumoniae) were more susceptible to all extracts compared to Gram positive bacteria (M.
luteus, B.
subtilis, and S.
aureus).
Methanol extract had the highest inhibition activity against all the tested microbes.
Moreover, methanolic extract of L.
camara contained 32 bioactive components as revealed by GC-MS study.
The identified major compounds included hexadecanoic acid (5.197%), phytol (4.528%), caryophyllene oxide (4.605%), and 9,12,15-octadecatrienoic acid, methyl ester, (Z,Z,Z)- (3.751%).
American Psychological Association (APA)
Swamy, Mallappa Kumara& Sinniah, Uma Rani& Akhtar, Mohd. Sayeed. 2015. In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1062394
Modern Language Association (MLA)
Swamy, Mallappa Kumara…[et al.]. In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1062394
American Medical Association (AMA)
Swamy, Mallappa Kumara& Sinniah, Uma Rani& Akhtar, Mohd. Sayeed. In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1062394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062394