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Genistein Attenuates Nonalcoholic Steatohepatitis and Increases Hepatic PPARγ in a Rat Model
Joint Authors
Thong-Ngam, Duangporn
Susutlertpanya, Warinda
Siriviriyakul, Prasong
Wisedopas, Naruemon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nonalcoholic steatohepatitis (NASH) has become a global chronic liver disease, but no effective medicine has been proven to cure it.
This study investigated the protective effects of genistein, a phytoestrogen, on NASH and examined whether it has any effect on hepatic PPARγ.
Male Sprague-Dawley rats were divided into four groups: control group fed ad libitum with standard rat diet, NASH group fed ad libitum with high-fat diet to induce NASH and NASH + Gen8 group and NASH + Gen16 group fed with high-fat diet plus intragastric administration of 8 or 16 mg/kg genistein once daily.
After 6 weeks, liver samples were collected to determine MDA, TNF-α, PPARγ, and histopathology.
The findings were that levels of hepatic MDA and TNF-α increased in NASH group, but 16 mg/kg genistein reduced these levels significantly.
Downregulation of hepatic PPARγ was observed in NASH group, but genistein significantly upregulated the expression of PPARγ in both NASH + Gen groups.
The histological appearance of liver in NASH group presented pathological features of steatohepatitis which were diminished in both NASH + Gen groups.
The results suggest that genistein attenuates the liver histopathology of NASH with upregulation of hepatic PPARγ, reduction of oxidative stress, and inhibition of inflammatory cytokine.
American Psychological Association (APA)
Susutlertpanya, Warinda& Thong-Ngam, Duangporn& Siriviriyakul, Prasong& Wisedopas, Naruemon. 2015. Genistein Attenuates Nonalcoholic Steatohepatitis and Increases Hepatic PPARγ in a Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1062402
Modern Language Association (MLA)
Susutlertpanya, Warinda…[et al.]. Genistein Attenuates Nonalcoholic Steatohepatitis and Increases Hepatic PPARγ in a Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1062402
American Medical Association (AMA)
Susutlertpanya, Warinda& Thong-Ngam, Duangporn& Siriviriyakul, Prasong& Wisedopas, Naruemon. Genistein Attenuates Nonalcoholic Steatohepatitis and Increases Hepatic PPARγ in a Rat Model. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1062402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062402