Effects of Hangeshashinto on Growth of Oral Microorganisms
Joint Authors
Kase, Yoshio
Omiya, Yuji
Fukamachi, Haruka
Matsumoto, Chinami
Arimoto, Takafumi
Morisaki, Hirobumi
Kataoka, Hideo
Kadena, Miki
Funatsu, Takahiro
Fukutake, Masato
Kuwata, Hirotaka
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oral mucositis (OM) in cancer patients induced by chemotherapy or radiotherapy has a significant impact on quality of life, and causes considerable morbidity.
Oral microorganisms are likely to intensify the inflammatory process and aggravate the formation of ulcers.
Hangeshashinto (HST), a Japanese kampo medicine, has been reported to be effective when used as a gargle for the treatment of OM.
To clarify the effects of HST on oral microorganisms, we assessed its antimicrobial activity against 27 microbial species, including 19 oral bacteria and one fungus.
HST extract inhibited the growth of Gram-negative bacteria, including Fusobacterium nucleatum, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia, Prevotella melaninogenica, Tannerella forsythia, Treponema denticola, and Porphyromonas asaccharolytica, though inhibitory effects were less pronounced for Gram-positive bacteria and the fungal strain.
We then investigated the effects of antibacterial activities on 15 purified ingredients of HST and determined that baicalein, berberine, coptisine, [6]-shogaol, and homogentisic acid actively inhibited the growth of these bacteria.
These findings showed that HST inhibits the growth of specific Gram-negative periodontopathogenic bacteria, which are significant pathogens in OM, without disturbing the normal oral flora.
Our data suggest that HST may be a useful treatment for OM in patients undergoing anticancer treatment.
American Psychological Association (APA)
Fukamachi, Haruka& Matsumoto, Chinami& Omiya, Yuji& Arimoto, Takafumi& Morisaki, Hirobumi& Kataoka, Hideo…[et al.]. 2015. Effects of Hangeshashinto on Growth of Oral Microorganisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1062404
Modern Language Association (MLA)
Fukamachi, Haruka…[et al.]. Effects of Hangeshashinto on Growth of Oral Microorganisms. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1062404
American Medical Association (AMA)
Fukamachi, Haruka& Matsumoto, Chinami& Omiya, Yuji& Arimoto, Takafumi& Morisaki, Hirobumi& Kataoka, Hideo…[et al.]. Effects of Hangeshashinto on Growth of Oral Microorganisms. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1062404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062404