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Evaluation of Toxicity and Antimicrobial Activity of an Ethanolic Extract from Leaves of Morus alba L. (Moraceae)
Joint Authors
Lima, Edeltrudes Oliveira
de Oliveira, Alisson Macário
Mesquita, Matheus da Silva
da Silva, Gabriela Cavalcante
Paiva, Patrícia Maria Guedes
Souza, Ivone Antônia de
de Medeiros, Paloma Lys
Napoleão, Thiago Henrique
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This work evaluated an ethanolic extract from Morus alba leaves for toxicity to Artemia salina, oral toxicity to mice, and antimicrobial activity.
Phytochemical analysis revealed the presence of coumarins, flavonoids, tannins, and triterpenes in the extract, which did not show toxicity to A.
salina nauplii.
No mortality and behavioral alterations were detected for mice treated with the extract (300 and 2000 mg/kg b.w.) for 14 days.
However, animals that received the highest dose showed reduced MCV and MCHC as well as increased serum alkaline phosphatase activity.
In treatments with the extract at both 300 and 2000 mg/kg, there was a reduction in number of leukocytes, with decrease in percentage of lymphocytes and increase in proportion of segmented cells.
Histopathological analysis of organs from mice treated with the extract at 2000 mg/kg revealed turgidity of contorted tubules in kidneys, presence of leukocyte infiltration around the liver centrilobular vein, and high dispersion of the spleen white pulp.
The extract showed antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, Candida krusei, Candida tropicalis, and Aspergillus flavus.
In conclusion, the extract contains antimicrobial agents and was not lethal for mice when ingested; however, its use requires caution because it promoted biochemical, hematological, and histopathological alterations.
American Psychological Association (APA)
de Oliveira, Alisson Macário& Mesquita, Matheus da Silva& da Silva, Gabriela Cavalcante& Lima, Edeltrudes Oliveira& de Medeiros, Paloma Lys& Paiva, Patrícia Maria Guedes…[et al.]. 2015. Evaluation of Toxicity and Antimicrobial Activity of an Ethanolic Extract from Leaves of Morus alba L. (Moraceae). Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1062405
Modern Language Association (MLA)
de Oliveira, Alisson Macário…[et al.]. Evaluation of Toxicity and Antimicrobial Activity of an Ethanolic Extract from Leaves of Morus alba L. (Moraceae). Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1062405
American Medical Association (AMA)
de Oliveira, Alisson Macário& Mesquita, Matheus da Silva& da Silva, Gabriela Cavalcante& Lima, Edeltrudes Oliveira& de Medeiros, Paloma Lys& Paiva, Patrícia Maria Guedes…[et al.]. Evaluation of Toxicity and Antimicrobial Activity of an Ethanolic Extract from Leaves of Morus alba L. (Moraceae). Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1062405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062405