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Relaxant Action of Plumula Nelumbinis Extract on Mouse Airway Smooth Muscle
Joint Authors
Chen, Weiwei
Tan, Li
Wei, Ming-Yu
Shen, Jinhua
Yu, Meng-Fei
Yang, Guangzhong
Guo, Donglin
Ji, Guangju
Liu, Qing-Hua
Qin, Gangjian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition.
However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated.
A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K+ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension.
CEPN also blocked voltage-dependent L-type Ca2+ channel- (VDCC-) mediated currents.
In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3.
Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents.
Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca2+ influx, resulting in relaxation of precontracted ASM.
This finding indicates that CEPN would be a candidate of new potent bronchodilators.
American Psychological Association (APA)
Tan, Li& Chen, Weiwei& Wei, Ming-Yu& Shen, Jinhua& Yu, Meng-Fei& Yang, Guangzhong…[et al.]. 2015. Relaxant Action of Plumula Nelumbinis Extract on Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1062415
Modern Language Association (MLA)
Tan, Li…[et al.]. Relaxant Action of Plumula Nelumbinis Extract on Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1062415
American Medical Association (AMA)
Tan, Li& Chen, Weiwei& Wei, Ming-Yu& Shen, Jinhua& Yu, Meng-Fei& Yang, Guangzhong…[et al.]. Relaxant Action of Plumula Nelumbinis Extract on Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1062415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062415