Natural Compounds Modulating Mitochondrial Functions
Joint Authors
Pinti, M.
Gibellini, Lara
Bianchini, Elena
De Biasi, Sara
Nasi, Milena
Cossarizza, Andrea
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Mitochondria are organelles responsible for several crucial cell functions, including respiration, oxidative phosphorylation, and regulation of apoptosis; they are also the main intracellular source of reactive oxygen species (ROS).
In the last years, a particular interest has been devoted to studying the effects on mitochondria of natural compounds of vegetal origin, quercetin (Qu), resveratrol (RSV), and curcumin (Cur) being the most studied molecules.
All these natural compounds modulate mitochondrial functions by inhibiting organelle enzymes or metabolic pathways (such as oxidative phosphorylation), by altering the production of mitochondrial ROS and by modulating the activity of transcription factors which regulate the expression of mitochondrial proteins.
While Qu displays both pro- and antioxidant activities, RSV and Cur are strong antioxidant, as they efficiently scavenge mitochondrial ROS and upregulate antioxidant transcriptional programmes in cells.
All the three compounds display a proapoptotic activity, mediated by the capability to directly cause the release of cytochrome c from mitochondria or indirectly by upregulating the expression of proapoptotic proteins of Bcl-2 family and downregulating antiapoptotic proteins.
Interestingly, these effects are particularly evident on proliferating cancer cells and can have important therapeutic implications.
American Psychological Association (APA)
Gibellini, Lara& Bianchini, Elena& De Biasi, Sara& Nasi, Milena& Cossarizza, Andrea& Pinti, M.. 2015. Natural Compounds Modulating Mitochondrial Functions. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1062480
Modern Language Association (MLA)
Bianchini, Elena…[et al.]. Natural Compounds Modulating Mitochondrial Functions. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1062480
American Medical Association (AMA)
Gibellini, Lara& Bianchini, Elena& De Biasi, Sara& Nasi, Milena& Cossarizza, Andrea& Pinti, M.. Natural Compounds Modulating Mitochondrial Functions. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1062480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062480