Bacopa monnieri Extract (CDRI-08) Modulates the NMDA Receptor Subunits and nNOS-Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats
Joint Authors
Mondal, Papia
Trigun, Surendra Kumar
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hepatic encephalopathy (HE), characterized by impaired cerebellar functions during chronic liver failure (CLF), involves N-methyl-D-aspartate receptor (NMDAR) overactivation in the brain cells.
Bacopa monnieri (BM) extract is a known neuroprotectant.
The present paper evaluates whether BM extract is able to modulate the two NMDAR subunits (NR2A and NR2B) and its downstream mediators in cerebellum of rats with chronic liver failure (CLF), induced by administration of 50 mg/kg bw thioacetamide (TAA) i.p.
for 14 days, and in the TAA group rats orally treated with 200 mg/kg bw BM extract from days 8 to 14.
NR2A is known to impart neuroprotection and that of NR2B induces neuronal death during NMDAR activation.
Neuronal nitric oxide synthase- (nNOS-) apoptosis pathway is known to mediate NMDAR led excitotoxicity.
The level of NR2A was found to be significantly reduced with a concomitant increase of NR2B in cerebellum of the CLF rats.
This was consistent with significantly enhanced nNOS expression, nitric oxide level, and reduced Bcl2/Bax ratio.
Moreover, treatment with BM extract reversed the NR2A/NR2B ratio and also normalized the levels of nNOS-apoptotic factors in cerebellum of those rats.
The findings suggest modulation of NR2A and NR2B expression by BM extract to prevent neurochemical alterations associated with HE.
American Psychological Association (APA)
Mondal, Papia& Trigun, Surendra Kumar. 2015. Bacopa monnieri Extract (CDRI-08) Modulates the NMDA Receptor Subunits and nNOS-Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1062487
Modern Language Association (MLA)
Mondal, Papia& Trigun, Surendra Kumar. Bacopa monnieri Extract (CDRI-08) Modulates the NMDA Receptor Subunits and nNOS-Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1062487
American Medical Association (AMA)
Mondal, Papia& Trigun, Surendra Kumar. Bacopa monnieri Extract (CDRI-08) Modulates the NMDA Receptor Subunits and nNOS-Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1062487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1062487