Effect of Compound Chuanxiong Capsule on Inflammatory Reaction and PI3KAktNF-κB Signaling Pathway in Atherosclerosis
Joint Authors
Kang, Qunfu
Liu, Weihong
Zhou, Mingxue
Liu, Hong-Xu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Compound Chuanxiong Capsule (CCC), a Chinese herbal compound, can exhibit antiatherosclerotic effect; however, its mechanism is still unclear.
This study is designed to study the mechanism of CCC on atherosclerosis in the ApoE-knockout (ApoE−/−) mice fed with a high-fat diet.
After 6 weeks of high-fat feeding, 40 ApoE−/− mice were randomized ( n = 10 ) and treated with lipitor, high-dose or low-dose CCC, or distilled water (ApoE−/− group) for 7 weeks.
The blood lipids in serum and the plaque areas of the mice were measured and the mRNA expressions of phosphatidylinositol-3-kinases (PI3K), Akt, nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) of the aortae were determined.
The data showed that CCC can significantly decrease the levels of blood lipids, atherosclerosis index, and plaque areas and increase collagen proportion in plaques as compared with the untreated mice ( p < 0.05 , p < 0.01 ).
In addition, CCC can significantly reduce the mRNA expressions of PI3K, Akt, NF-κB, IL-6, and TNF-α in the mice fed with a high-fat diet ( p < 0.001 ).
Thus, we concluded that CCC can inhibit inflammatory reaction in the ApoE−/− mice fed with a high-fat diet.
This mechanism may be attributed to regulating PI3K/Akt/NF-κB signaling pathway.
American Psychological Association (APA)
Kang, Qunfu& Liu, Weihong& Liu, Hong-Xu& Zhou, Mingxue. 2015. Effect of Compound Chuanxiong Capsule on Inflammatory Reaction and PI3KAktNF-κB Signaling Pathway in Atherosclerosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063352
Modern Language Association (MLA)
Kang, Qunfu…[et al.]. Effect of Compound Chuanxiong Capsule on Inflammatory Reaction and PI3KAktNF-κB Signaling Pathway in Atherosclerosis. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063352
American Medical Association (AMA)
Kang, Qunfu& Liu, Weihong& Liu, Hong-Xu& Zhou, Mingxue. Effect of Compound Chuanxiong Capsule on Inflammatory Reaction and PI3KAktNF-κB Signaling Pathway in Atherosclerosis. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063352