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Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats
Joint Authors
Yi, Zhang
Shao-long, Yang
Ai-hong, Wang
Zhi-chun, Sun
Ya-fen, Zhuo
Ye-ting, Xu
Yu-ling, He
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We investigated the effects of Hericium erinaceus (HEE) on alloxan induced diabetic neuropathic pain in laboratory rats.
Alloxan induced diabetic rats were administered orally HEE.
After 6 weeks of treatments, treatment with HEE 40 mg/kg in diabetic animals showed significant increase in pain threshold and paw withdrawal threshold and significant decrease in serum glucose and urine glucose.
We also observed a significant increase in lactate dehydrogenase (LDH), Lipid peroxidation (LPO), glutathione peroxidase (GPx) activity, glutathione reductase (GR) activity, catalase (CAT) activity, Na+K+ATPase activity, and glutathione S transferase (GST) activity along with significant decreased levels of glutathione (GSH) content in diabetic rats.
The total antioxidant status (TAOS) in the HEE-treated groups was significantly lower than that in the alloxan-treated group.
HEE can offer pain relief in diabetic neuropathic pain.
The improvement in diabetic state after HEE treatment along with the antioxidant activity could be the probable way by which it had alleviated diabetic neuropathy.
American Psychological Association (APA)
Yi, Zhang& Shao-long, Yang& Ai-hong, Wang& Zhi-chun, Sun& Ya-fen, Zhuo& Ye-ting, Xu…[et al.]. 2015. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063363
Modern Language Association (MLA)
Yi, Zhang…[et al.]. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1063363
American Medical Association (AMA)
Yi, Zhang& Shao-long, Yang& Ai-hong, Wang& Zhi-chun, Sun& Ya-fen, Zhuo& Ye-ting, Xu…[et al.]. Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063363