Supplementation of Citrus maxima Peel Powder Prevented Oxidative Stress, Fibrosis, and Hepatic Damage in Carbon Tetrachloride (CCl4) Treated Rats
Joint Authors
Hossain, Hemayet
Chowdhury, Mohammed Riaz Hasan
Sagor, Md Abu Taher
Tabassum, Nabila
Potol, Md Abdullah
Alam, Md. Ashraful
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Citrus maxima peel is rich in natural phenolic compounds and has a long use in the traditional medicine.
HPLC-DAD analysis on Citrus maxima peel powder exhibited the presence of various phenolic compounds such as caffeic acid and (−)-epicatechin.
To determine the plausible hepatoprotective activity of Citrus maxima peel powder, we used carbon tetrachloride (CCl4) treated rat model.
Liver damage in rats was confirmed by measuring the AST, ALT, and ALP enzyme activities.
In addition, lipid peroxidation products (MDA), nitric oxide, advanced protein oxidation products level (APOP), and catalase activities were also analyzed along with the histological profiling for the inflammatory cell infiltration, collagen, and iron deposition in liver.
Dietary supplementation of Citrus maxima peel powder exhibited significant reduction of serum AST, ALT, and ALP activities in carbon tetrachloride treated rats.
Moreover, Citrus maxima peel powder also showed a significant reduction of the oxidative stress markers (MDA, NO, and APOP level) and restored the catalase activity in CCl4 treated rats.
Histological examination of the liver section revealed reduced inflammatory cells infiltration, collagen, and iron deposition in CCl4 treated rats.
The results from this study demonstrated that Citrus maxima peel powder produced significant hepatoprotective action in CCl4 administered rats.
American Psychological Association (APA)
Chowdhury, Mohammed Riaz Hasan& Sagor, Md Abu Taher& Tabassum, Nabila& Potol, Md Abdullah& Hossain, Hemayet& Alam, Md. Ashraful. 2015. Supplementation of Citrus maxima Peel Powder Prevented Oxidative Stress, Fibrosis, and Hepatic Damage in Carbon Tetrachloride (CCl4) Treated Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063366
Modern Language Association (MLA)
Chowdhury, Mohammed Riaz Hasan…[et al.]. Supplementation of Citrus maxima Peel Powder Prevented Oxidative Stress, Fibrosis, and Hepatic Damage in Carbon Tetrachloride (CCl4) Treated Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063366
American Medical Association (AMA)
Chowdhury, Mohammed Riaz Hasan& Sagor, Md Abu Taher& Tabassum, Nabila& Potol, Md Abdullah& Hossain, Hemayet& Alam, Md. Ashraful. Supplementation of Citrus maxima Peel Powder Prevented Oxidative Stress, Fibrosis, and Hepatic Damage in Carbon Tetrachloride (CCl4) Treated Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063366