![](/images/graphics-bg.png)
Inhibitory Effects of Chemical Compounds Isolated from the Rhizome of Smilax glabra on Nitric Oxide and Tumor Necrosis Factor-α Production in Lipopolysaccharide-Induced RAW264.7 Cell
Joint Authors
Lu, Chuanjian
Xu, Xiaojie
Lu, Chuan-li
Zhu, Wei
Wang, Dong-mei
Chen, Wen-long
Hu, Meng-mei
Wang, Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The rhizome of Smilax glabra has been used for a long time as both food and folk medicine in many countries.
The present study focused on the active constituents from the rhizome of S.
glabra, which possess potential anti-inflammatory activities.
As a result, nine known compounds were isolated from the rhizome of S.
glabra with the bioassay-guiding, and were identified as syringaresinol (1), lasiodiplodin (2), de-O-methyllasiodiplodin (3), syringic acid (4), 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol (5), lyoniresinol (6), trans-resveratrol (7), trans-caffeic acid methyl ester (8), and dihydrokaempferol (9).
Among these compounds, 2 and 3 were isolated for the first time from S.
glabra.
In addition, the potential anti-inflammatory activities of the isolated compounds were evaluated in vitro in lipopolysaccharide- (LPS-) induced RAW264.7 cells.
Results indicated that 4 and 7 showed significant inhibitory effects on NO production of RAW264.7 cells, and 1, 2, 3, and 5 showed moderate suppression effects on induced NO production.
1, 7, and 5 exhibited high inhibitory effects on TNF-α production, with the IC50 values less than 2.3, 4.4, and 16.6 μM, respectively.
These findings strongly suggest that compounds 1, 2, 3, 4, 5, 7, and 9 were the potential anti-inflammatory active compositions of S.
glabra.
American Psychological Association (APA)
Lu, Chuan-li& Zhu, Wei& Wang, Dong-mei& Chen, Wen-long& Hu, Meng-mei& Wang, Min…[et al.]. 2015. Inhibitory Effects of Chemical Compounds Isolated from the Rhizome of Smilax glabra on Nitric Oxide and Tumor Necrosis Factor-α Production in Lipopolysaccharide-Induced RAW264.7 Cell. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063370
Modern Language Association (MLA)
Lu, Chuan-li…[et al.]. Inhibitory Effects of Chemical Compounds Isolated from the Rhizome of Smilax glabra on Nitric Oxide and Tumor Necrosis Factor-α Production in Lipopolysaccharide-Induced RAW264.7 Cell. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063370
American Medical Association (AMA)
Lu, Chuan-li& Zhu, Wei& Wang, Dong-mei& Chen, Wen-long& Hu, Meng-mei& Wang, Min…[et al.]. Inhibitory Effects of Chemical Compounds Isolated from the Rhizome of Smilax glabra on Nitric Oxide and Tumor Necrosis Factor-α Production in Lipopolysaccharide-Induced RAW264.7 Cell. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063370