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Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Panax ginseng extracts are used in traditional herbal medicines, particularly in eastern Asia, but their effect on natural killer (NK) cell activity is not completely understood.
This study aimed to examine the effects of P.
ginseng extracts on the cytotoxic activity of NK cells.
We orally administered P.
ginseng extracts or ginsenosides to wild-type (WT) C57BL/6 (B6) and BALB/c mice and to B6 mice deficient in either recombination activating gene 2 (RAG-2) or interferon-γ (IFN-γ).
We then tested the cytotoxic activity of NK cells (of spleen and liver mononuclear cells) against NK-sensitive YAC-1 cells.
Oral administration of P.
ginseng aqueous extract augmented the cytotoxicity of NK cells in WT B6 and BALB/c mice and in RAG-2-deficient B6 mice, but not in IFN-γ-deficient B6 mice.
This effect was only observed with the aqueous extract of P.
ginseng.
Interestingly, the ginsenosides Rb1 and Rg1 did not augment NK cell cytotoxicity.
These results demonstrated that the aqueous P.
ginseng extract augmented NK cell activation in vivo via an IFN-γ-dependent pathway.
American Psychological Association (APA)
Takeda, Kazuyoshi& Okumura, Ko. 2015. Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063372
Modern Language Association (MLA)
Takeda, Kazuyoshi& Okumura, Ko. Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063372
American Medical Association (AMA)
Takeda, Kazuyoshi& Okumura, Ko. Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063372