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Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips
Joint Authors
Mendel, Marta
Skalicka-Woźniak, Krystyna
Chłopecka, Magdalena
Dziekan, Natalia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Imperatorin, a psoralen-type furanocoumarin, is a potent myorelaxant agent acting as a calcium antagonist on vascular smooth muscle.
Its effects on other types of smooth muscle remain unknown.
Therefore, the aim of this study was to investigate the hypothesized myorelaxant effect of imperatorin on gut motor activity and, possibly, to define the underlying mechanism of action.
Imperatorin was made available for pharmacological studies from the fruits of the widely available Angelica officinalis through the application of high-performance countercurrent chromatography (HPCCC).
Imperatorin generated reversible relaxation of jejunum strips dose-dependently (1–100 μM).
At 25 and 50 μM, imperatorin caused relaxation comparable to the strength of the reaction induced by isoproterenol (Isop) at 0.1 μM.
The observed response resulted neither from the activation of soluble guanylate cyclase, nor from β-adrenoreceptor involvement, nor from Ca2+-activated potassium channels.
Imperatorin relaxed intestine strips precontracted with high potassium concentration, attenuated the force and duration of K+-induced contractions, and modulated the response of jejunum strips to acetylcholine.
The results suggest that imperatorin probably interacts with various Ca2+ influx pathways in intestine smooth muscle.
The types of some calcium channels involved in the activity of imperatorin will be examined in a subsequent study.
American Psychological Association (APA)
Mendel, Marta& Skalicka-Woźniak, Krystyna& Chłopecka, Magdalena& Dziekan, Natalia. 2015. Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063382
Modern Language Association (MLA)
Mendel, Marta…[et al.]. Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063382
American Medical Association (AMA)
Mendel, Marta& Skalicka-Woźniak, Krystyna& Chłopecka, Magdalena& Dziekan, Natalia. Effect of Imperatorin on the Spontaneous Motor Activity of Rat Isolated Jejunum Strips. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063382