Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract from Camellia euphlebia Merr. ex Sealy in Mice
Joint Authors
Wang, Xitao
Wang, Lili
Li, Xiaoyu
He, Dongye
Zhang, Ping
Luo, Xinxing
Li, Shuying
Xu, Yongping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Camellia euphlebia Merr.
ex Sealy is a traditional Chinese medicine that has been widely used for improvement of human emotions in the Guangxi Province of southern China.
However, there are no studies about the anxiolytic and antidepressant activities of Camellia euphlebia.
This study evaluated the anxiolytic and antidepressant activities of the aqueous extract from Camellia euphlebia (CEE) in mice.
We found that administration of 400 mg/kg CEE or 20 mg/kg fluoxetine for 7 days significantly reduced the immobility time in both TST and FST.
Oral administration of 100 mg/kg extract or 4 mg/kg diazepam for 7 days significantly increased the percentage of time spent and the number of entries into the open arms of the EPMT.
In addition, the time spent by mice in the illuminated side of the LDBT was increased.
Furthermore, pretreatment with 400 mg/kg CEE for 7 days significantly elevated the level of 5-HT and DA in the whole brain of mice.
These results provide support for the potential anxiolytic and antidepressant activity of Camellia euphlebia and contribute towards validation of the traditional use of Camellia euphlebia in the treatment of emotional disorders.
American Psychological Association (APA)
He, Dongye& Wang, Xitao& Zhang, Ping& Luo, Xinxing& Li, Xiaoyu& Wang, Lili…[et al.]. 2015. Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract from Camellia euphlebia Merr. ex Sealy in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063388
Modern Language Association (MLA)
He, Dongye…[et al.]. Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract from Camellia euphlebia Merr. ex Sealy in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063388
American Medical Association (AMA)
He, Dongye& Wang, Xitao& Zhang, Ping& Luo, Xinxing& Li, Xiaoyu& Wang, Lili…[et al.]. Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract from Camellia euphlebia Merr. ex Sealy in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063388