![](/images/graphics-bg.png)
A Novel Korean Red Ginseng Compound Gintonin Inhibited Inflammation by MAPK and NF-κB Pathways and Recovered the Levels of mir-34a and mir-93 in RAW 264.7 Cells
Joint Authors
Jeon, Bo Ra
Kwak, Dong-Mi
Goo, Youn-Kyoung
Kim, Sung Dae
Saba, Evelyn
Jeong, Da-Hye
Lee, Kija
Kim, Suk
Rhee, Man Hee
Roh, Seong-Soo
Nah, S. Y.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The beneficial health promoting effects of ginseng from vitalizing the body to enhancing long life have been well explored very rapidly in the past few years.
Up till now many ginsenosides have been discovered for their marvelous therapeutic effects.
However during past three years, a novel ginseng compound has been discovered, called gintonin, that differs from other ginsenosides on the basis of its signal transduction and chemical nature.
Gintonin has been widely studied for its anti-Alzheimer’s disease activities and other neuropathies.
However, its anti-inflammatory activity remained unexplored.
In our study we have reported for the first time the anti-inflammatory activity of gintonin on RAW 264.7 cells.
We found that gintonin potently suppresses the nitric oxide production without any cytotoxicity at given doses and also efficiently suppressed the levels of proinflammatory cytokines.
Moreover, it mediaes its signal transduction via MAPK and NF-κB pathways and revives the levels of mir-34a and mir-93.
These findings are valuable for the anti-inflammatory effects of this new compound with particular reference to microRNA involvement in the ginseng family.
American Psychological Association (APA)
Saba, Evelyn& Jeon, Bo Ra& Jeong, Da-Hye& Lee, Kija& Goo, Youn-Kyoung& Kwak, Dong-Mi…[et al.]. 2015. A Novel Korean Red Ginseng Compound Gintonin Inhibited Inflammation by MAPK and NF-κB Pathways and Recovered the Levels of mir-34a and mir-93 in RAW 264.7 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063396
Modern Language Association (MLA)
Saba, Evelyn…[et al.]. A Novel Korean Red Ginseng Compound Gintonin Inhibited Inflammation by MAPK and NF-κB Pathways and Recovered the Levels of mir-34a and mir-93 in RAW 264.7 Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063396
American Medical Association (AMA)
Saba, Evelyn& Jeon, Bo Ra& Jeong, Da-Hye& Lee, Kija& Goo, Youn-Kyoung& Kwak, Dong-Mi…[et al.]. A Novel Korean Red Ginseng Compound Gintonin Inhibited Inflammation by MAPK and NF-κB Pathways and Recovered the Levels of mir-34a and mir-93 in RAW 264.7 Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063396