In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism
Joint Authors
Kim, In Sook
Han, Young Min
Rehman, Shaheed Ur
Choe, Kevin
Yoo, Hye Hyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Eurycoma longifolia (Simaroubaceae) is a popular folk medicine that has traditionally been used in Southeast Asia as an antimalarial, aphrodisiac, antidiabetic, and antimicrobial and in antipyretic remedies.
This study evaluates the effects of Eurycoma longifolia extract on cytochrome P450 (CYP) enzyme-mediated drug metabolism to predict the potential for herb-drug interactions.
Methanolic extract of E.
longifolia root was tested at concentrations of 1, 3, 10, 30, 100, 300, and 1000 µg/mL in human liver microsomes or individual recombinant CYP isozymes.
The CYP inhibitory activity was measured using the cocktail probe assay based on liquid chromatography-tandem mass spectrometry.
E.
longifolia showed weak, concentration-dependent inhibition of CYP1A2, CYP2A6, and CYP2C19.
The inhibitory effects on these CYP isozymes were further tested using individual recombinant CYP isozymes, showing IC50 values of 324.9, 797.1, and 562.9 μg/mL, respectively.
In conclusion, E.
longifolia slightly inhibited the metabolic activities of CYP1A2, CYP2A6, and CYP2C19 but this issue requires careful attention in taking herbal medicines or dietary supplements containing E.
longifolia extracts.
American Psychological Association (APA)
Han, Young Min& Kim, In Sook& Rehman, Shaheed Ur& Choe, Kevin& Yoo, Hye Hyun. 2015. In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063405
Modern Language Association (MLA)
Han, Young Min…[et al.]. In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063405
American Medical Association (AMA)
Han, Young Min& Kim, In Sook& Rehman, Shaheed Ur& Choe, Kevin& Yoo, Hye Hyun. In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063405