Shenqi Fuzheng Injection Combined with Chemotherapy for Breast Cancer: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Lv, Yanhong
Zhang, Guijuan
Ma, Yi
Ma, Min
Liao, Rui
Xiang, Jingfang
Chen, Ruixue
Yan, Xianxin
Bie, Fengjie
Huang, Maojie
Liang, Shijie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Purpose.
To evaluate the therapeutic effectiveness and safety of shenqi fuzheng injection (SFI) in the associated chemotherapy of breast cancer.
Methods.
1247 subjects were included in this study for meta-analysis with RevMan 5.3.
Results.
The clinical curative effective rate (OR = 2.03, 95% Cl [1.44, 2.86], P < 0.0001 ), grades of KPS (OR = 4.11, 95% Cl [2.74, 6.16], P < 0.00001 ), CD3+ cells (MD = 7.05, 95% Cl [0.45, 13.64], P = 0.04 ) and CD4+ cells (MD = 8.60, 95% Cl [2.67, 14.54], P = 0.004 ) and CD4/CD8+ cells (MD = 0.35, 95% Cl [0.14, 0.56], P = 0.001 ), WBC (OR = 0.30, 95% Cl [0.20, 0.46], P ≤ 0.0001 ), PLT (OR = 0.36, 95% Cl [0.20, 0.67], P = 0.001 ), gastrointestinal reaction (OR = 0.21, 95% Cl [0.14, 0.32], P < 0.00001 ), and ECG (OR = 0.26, 95% Cl [0.13, 0.51], P < 0.0001 ) in the experimental group were superior to the control group.
While there were no differences between two groups in CD8+ (MD = 0.21, 95% Cl [−2.81, 3.23], P = 0.89 ), NK+ (MD = 1.06, 95% Cl [−9.40, 11.53], P = 0.84 ), RBC (OR = 0.49, 95% Cl [0.14, 1.74], P = 0.27 ), liver function (OR = 0.59, 95% Cl [0.28, 1.24], P = 0.16 ), renal function (OR = 0.56, 95% Cl [0.13, 2.45], P = 0.44 ), and bone marrow suppression (OR = 0.50, 95% Cl [0.25, 1.01], P = 0.05 ).
Conclusion.
SFI combined with chemotherapy, to some extent, can improve the effectiveness and the security in the treatment of breast cancer; the mechanism may be related to the elevated immunity.
American Psychological Association (APA)
Lv, Yanhong& Zhang, Guijuan& Ma, Yi& Ma, Min& Liao, Rui& Xiang, Jingfang…[et al.]. 2015. Shenqi Fuzheng Injection Combined with Chemotherapy for Breast Cancer: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1063410
Modern Language Association (MLA)
Lv, Yanhong…[et al.]. Shenqi Fuzheng Injection Combined with Chemotherapy for Breast Cancer: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1063410
American Medical Association (AMA)
Lv, Yanhong& Zhang, Guijuan& Ma, Yi& Ma, Min& Liao, Rui& Xiang, Jingfang…[et al.]. Shenqi Fuzheng Injection Combined with Chemotherapy for Breast Cancer: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1063410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063410