Effects of Qili Qiangxin Capsule on AQP2, V2R, and AT1R in Rats with Chronic Heart Failure
Joint Authors
Cui, Xiang-Ning
Zhao, Yi-Zhou
Cao, Jian
Zhao, Xin
Zhang, Jian
Li, Yubo
Sun, Yuxiu
He, Yaoyao
Han, Anbang
Zhao, Mingjing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Qili qiangxin capsule (QL), a traditional Chinese herbal compound, has been proved to be effective and safe for the treatment of chronic heart failure (CHF).
Upregulation of aquaporin-2 (AQP2) accounts for the water retention in CHF.
The aim of the present study was to evaluate the effects of QL on the expression of AQP2 in rats with CHF induced by acute myocardial infarction and to investigate the underlying mechanisms.
The urine output of all rats was quantified and collected every day at the first week and the 4th week after administration of QL or Valsartan.
The expression of AQP2, vasopressin type 2 receptor (V2R), and angiotensin II type 1 receptor (AT1R) were examined after treatment for 4 weeks.
Urinary output increased significantly after administration of QL.
Importantly, the protein expression of AQP2 and AQP2 phosphorylated at serine 256 (pS256-AQP2) was downregulated after administration of QL and Valsartan to CHF rats.
Furthermore, QL reduced plasma arginine vasopressin (AVP) and angiotensin II (AngII) level and downregulated V2R and AT1R protein expression.
Thus, QL exerts its diuretic effect and improves cardiac function in CHF rats by reversing the increases in both AQP2 and pS256-AQP2 expression.
The possible mechanisms may involve inhibition of V2R and AT1R.
American Psychological Association (APA)
Cui, Xiang-Ning& Zhang, Jian& Li, Yubo& Sun, Yuxiu& Cao, Jian& Zhao, Mingjing…[et al.]. 2015. Effects of Qili Qiangxin Capsule on AQP2, V2R, and AT1R in Rats with Chronic Heart Failure. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063416
Modern Language Association (MLA)
Cui, Xiang-Ning…[et al.]. Effects of Qili Qiangxin Capsule on AQP2, V2R, and AT1R in Rats with Chronic Heart Failure. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063416
American Medical Association (AMA)
Cui, Xiang-Ning& Zhang, Jian& Li, Yubo& Sun, Yuxiu& Cao, Jian& Zhao, Mingjing…[et al.]. Effects of Qili Qiangxin Capsule on AQP2, V2R, and AT1R in Rats with Chronic Heart Failure. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063416