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Methyl Protodioscin from the Roots of Asparagus cochinchinensis Attenuates Airway Inflammation by Inhibiting Cytokine Production
Joint Authors
Lee, Ju Hee
Lim, Hun Jai
Lee, Chan Woo
Son, Jong-Keun
Lee, Sang Kook
Kim, Hyun Pyo
Son, Kun-Ho
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The present study was designed to find pharmacologically active compound against airway inflammation from the roots of Asparagus cochinchinensis.
The 70% ethanol extract of the roots of A.
cochinchinensis (ACE) was found to inhibit IL-6 production from IL-1β-treated lung epithelial cells (A549) and the major constituent, methyl protodioscin (MP), also strongly inhibited the production of IL-6, IL-8, and tumor necrosis factor- (TNF-) α from A549 cells at 10–100 μM.
This downregulating effect of proinflammatory cytokine production was found to be mediated, at least in part, via inhibition of c-Jun N-terminal kinase (JNK) and c-Jun activation pathway.
When examined on an in vivo model of airway inflammation in mice, lipopolysaccharide- (LPS-) induced acute lung injury, ACE, and MP significantly inhibited cell infiltration in the bronchoalveolar lavage fluid by the oral treatment at doses of 100–400 mg/kg and 30–60 mg/kg, respectively.
MP also inhibited the production of proinflammatory cytokines such as IL-6, TNF-α, and IL-1β in lung tissue.
All of these findings provide scientific evidence supporting the role of A.
cochinchinensis as a herbal remedy in treating airway inflammation and also suggest a therapeutic value of MP on airway inflammatory disorders.
American Psychological Association (APA)
Lee, Ju Hee& Lim, Hun Jai& Lee, Chan Woo& Son, Kun-Ho& Son, Jong-Keun& Lee, Sang Kook…[et al.]. 2015. Methyl Protodioscin from the Roots of Asparagus cochinchinensis Attenuates Airway Inflammation by Inhibiting Cytokine Production. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063417
Modern Language Association (MLA)
Lee, Ju Hee…[et al.]. Methyl Protodioscin from the Roots of Asparagus cochinchinensis Attenuates Airway Inflammation by Inhibiting Cytokine Production. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063417
American Medical Association (AMA)
Lee, Ju Hee& Lim, Hun Jai& Lee, Chan Woo& Son, Kun-Ho& Son, Jong-Keun& Lee, Sang Kook…[et al.]. Methyl Protodioscin from the Roots of Asparagus cochinchinensis Attenuates Airway Inflammation by Inhibiting Cytokine Production. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063417