Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats
Joint Authors
Liu, Jun Ling
Chen, Shu-ping
Qiao, Li-na
Zhang, Jian-liang
Gao, Yong-hui
Wang, Jun-ying
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Results of our past studies showed that hippocampal muscarinic acetylcholine receptor (mAChR)-1 mRNA and differentially expressed proteins participating in MAPK signaling were involved in electroacupuncture (EA) induced cumulative analgesia in neuropathic pain rats, but the underlying intracellular mechanism remains unknown.
The present study was designed to observe the effect of EA stimulation (EAS) on hippocampal extracellular signal-regulated kinases (ERK) and p38 MAPK signaling in rats with chronic constrictive injury (CCI) of the sciatic nerve, so as to reveal its related intracellular targets in pain relief.
After CCI, the thermal pain thresholds of the affected hind were significantly decreased compared with the control group (P<0.05).
Following one and two weeks’ EAS of ST 36-GB34, the pain thresholds were significantly upregulated (P<0.05), and the effect of EA2W was remarkably superior to that of EA2D and EA1W (P<0.05).
Correspondingly, CCI-induced decreased expression levels of Ras, c-Raf, ERK1 and p-ERK1/2 proteins, and p38 MAPK mRNA and p-p38MAPK protein in the hippocampus tissues were reversed by EA2W (P<0.05).
The above mentioned results indicated that EA2W induced cumulative analgesic effect may be closely associated with its function in removing neuropathic pain induced suppression of intracellular ERK and p38MAPK signaling in the hippocampus.
American Psychological Association (APA)
Wang, Jun-ying& Chen, Shu-ping& Gao, Yong-hui& Qiao, Li-na& Zhang, Jian-liang& Liu, Jun Ling. 2015. Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063418
Modern Language Association (MLA)
Wang, Jun-ying…[et al.]. Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063418
American Medical Association (AMA)
Wang, Jun-ying& Chen, Shu-ping& Gao, Yong-hui& Qiao, Li-na& Zhang, Jian-liang& Liu, Jun Ling. Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063418