Effects of Electroacupuncture on Chronic Unpredictable Mild Stress Rats Depression-Like Behavior and Expression of p-ERKERK and p-P38P38
Joint Authors
Xu, Jian
She, Yanling
Su, Ning
Zhang, Ruixin
Lao, Lixing
Xu, Shifen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigate the antidepressant-like effect and mechanism of electroacupuncture (EA) on a chronic unpredictable mild stress rats depression-like behavior.
In our study, depression in rats was induced by unpredictable chronic mild stress (UCMS) and isolation for four weeks.
Male Sprague-Dawley rats were randomly divided into four groups: Normal, Model, EA, and Sham EA.
EA treatment was administered for two weeks, once a day for five days a week.
Two acupoints, Yintang (EX-HN3) and Baihui (GV20), were selected.
For sham EA, acupuncture needles were inserted shallowly into the acupoints: EX-HN3 and GV20.
No electrostimulator was connected.
The antidepressant-like effect of the electroacupuncture treatment was measured by sucrose intake test, open field test, and forced swimming test in rats.
The protein levels of phosphorylated extracellular regulated protein kinases (p-ERK1/2)/ERK1/2 and p-P38/P38 in the hippocampus (HP) were examined by Western blot analysis.
Our data demonstrate that EA treatment decreased the immobility time of forced swimming test and improved the sucrose solution intake in comparison to unpredictable chronic mild stress and placebo sham control.
Electroacupuncture may act on depression by enhancing p-ERK1/2 and p-p38 in the hippocampus.
American Psychological Association (APA)
Xu, Jian& She, Yanling& Su, Ning& Zhang, Ruixin& Lao, Lixing& Xu, Shifen. 2015. Effects of Electroacupuncture on Chronic Unpredictable Mild Stress Rats Depression-Like Behavior and Expression of p-ERKERK and p-P38P38. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063434
Modern Language Association (MLA)
Xu, Jian…[et al.]. Effects of Electroacupuncture on Chronic Unpredictable Mild Stress Rats Depression-Like Behavior and Expression of p-ERKERK and p-P38P38. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063434
American Medical Association (AMA)
Xu, Jian& She, Yanling& Su, Ning& Zhang, Ruixin& Lao, Lixing& Xu, Shifen. Effects of Electroacupuncture on Chronic Unpredictable Mild Stress Rats Depression-Like Behavior and Expression of p-ERKERK and p-P38P38. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063434