Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases
Joint Authors
Atanasov, Atanas G.
Heiss, E. H.
Blažević, Tina
Breuss, Johannes M.
Uhrin, Pavel
Dirsch, V. M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Indirubin is the active component of Danggui Longhui Wan, a traditional Chinese medicine formulation.
The encouraging clinical results from the 1980s obtained in chronic myelocytic leukemia patients treated with indirubin stimulated numerous studies on this compound.
These investigations explored the use of indirubin in different types of cancer and reported the synthesis of novel derivatives with improved chemical and pharmacokinetic properties.
In this paper, we review the impressive progress that has been made in elucidating the mechanistic understanding of how indirubin and its derivatives affect physiological and pathophysiological processes, mainly by inhibition of cell proliferation and induction of cell death.
Furthermore, we survey the therapeutic use of these compounds in combating proliferative diseases such as cancer, restenosis, and psoriasis.
American Psychological Association (APA)
Blažević, Tina& Heiss, E. H.& Atanasov, Atanas G.& Breuss, Johannes M.& Dirsch, V. M.& Uhrin, Pavel. 2015. Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063440
Modern Language Association (MLA)
Blažević, Tina…[et al.]. Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063440
American Medical Association (AMA)
Blažević, Tina& Heiss, E. H.& Atanasov, Atanas G.& Breuss, Johannes M.& Dirsch, V. M.& Uhrin, Pavel. Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063440