Maslinic Acid Enhances Signals for the Recruitment of Macrophages and Their Differentiation to M1 State
Joint Authors
Sánchez-Quesada, Cristina
López-Biedma, Alicia
Gaforio, José J.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The inflammatory process is involved in the genesis and evolution of different diseases like obesity, cardiovascular disease, and cancer.
Macrophages play a central role in inflammation.
In addition, they can regulate some stages of cancer development.
Macrophages can polarize into M1 or M2 functional phenotype depending on the cytokines present in the tissue microenvironment.
On the other hand, triterpenes found in virgin olive oil are described to present different properties, such as antitumoral and anti-inflammatory activity.
The present study was designed to elucidate if the four major triterpenes found in virgin olive oil (oleanolic acid, maslinic acid, uvaol, and erythrodiol) are able to enhance M1 macrophage response which represents an important defense mechanism against cancer.
Our results indicated that maslinic acid modulated the inflammatory response by enhancing the production of IL-8, IL-1α, and IL-1β; it promoted M1 response through the synthesis of IFN-γ; and finally it did not modify significantly the levels of NFκβ or NO.
Overall, our results showed that maslinic acid could prevent chronic inflammation, which represents a crucial step in the development of some cancers.
American Psychological Association (APA)
Sánchez-Quesada, Cristina& López-Biedma, Alicia& Gaforio, José J.. 2015. Maslinic Acid Enhances Signals for the Recruitment of Macrophages and Their Differentiation to M1 State. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063441
Modern Language Association (MLA)
Sánchez-Quesada, Cristina…[et al.]. Maslinic Acid Enhances Signals for the Recruitment of Macrophages and Their Differentiation to M1 State. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063441
American Medical Association (AMA)
Sánchez-Quesada, Cristina& López-Biedma, Alicia& Gaforio, José J.. Maslinic Acid Enhances Signals for the Recruitment of Macrophages and Their Differentiation to M1 State. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063441