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Danggui Buxue Tang Inhibits 2,4-Dinitrochlorobenzene: Induced Atopic Dermatitis in Mice
Joint Authors
Huang, Wen-Chung
Liou, Chian-Jiun
Fang, Li-Wen
Cheng, Chao-Chun
Hwang, Tzann-Shun
Chen, Wen-Chyuan
Wu, Shu-Ju
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Danggui Buxue Tang (DBT) is a herbal decoction that has been used in Chinese medicine to enhance qi and blood circulation.
Previously, we found that DBT can suppress allergy-related asthma in mice, leading us to hypothesize that DBT might ameliorate allergy disease.
In this study, we evaluated whether DBT can attenuate atopic dermatitis (AD) symptoms and have an anti-inflammatory effect on AD-like mice.
The dorsal skin of female mice was shaved and sensitized cutaneously (skin smear) with 1-chloro-2,4-dinitrobenzene.
Mice were then given various doses of DBT from days 14 to 29 cutaneously.
DBT treatment suppressed ear swelling and skin inflammation and decreased mast cell and eosinophil infiltration into skin and ear tissue.
DBT also inhibited levels of IgE and Th2-associated cytokine levels in serum.
These results demonstrate that cutaneous administration of DBT reduced the development of AD-like skin lesions in mice.
American Psychological Association (APA)
Fang, Li-Wen& Cheng, Chao-Chun& Hwang, Tzann-Shun& Huang, Wen-Chung& Liou, Chian-Jiun& Chen, Wen-Chyuan…[et al.]. 2015. Danggui Buxue Tang Inhibits 2,4-Dinitrochlorobenzene: Induced Atopic Dermatitis in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063448
Modern Language Association (MLA)
Fang, Li-Wen…[et al.]. Danggui Buxue Tang Inhibits 2,4-Dinitrochlorobenzene: Induced Atopic Dermatitis in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063448
American Medical Association (AMA)
Fang, Li-Wen& Cheng, Chao-Chun& Hwang, Tzann-Shun& Huang, Wen-Chung& Liou, Chian-Jiun& Chen, Wen-Chyuan…[et al.]. Danggui Buxue Tang Inhibits 2,4-Dinitrochlorobenzene: Induced Atopic Dermatitis in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063448