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Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice
Joint Authors
Lee, Chen-Chen
Huang, Huei-Mei
Lin, Chu-Lun
Lee, Yueh-Lun
Wang, Ching-Chiung
Leu, Sy-Jye
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
This study investigated the immunomodulatory effects of ferulic acid (FA) on antigen-presenting dendritic cells (DCs) in vitro and its antiallergic effects against ovalbumin- (OVA-) induced Th2-mediated allergic asthma in mice.
The activation of FA-treated bone marrow-derived DCs by lipopolysaccharide (LPS) stimulation induced a high level of interleukin- (IL-) 12 but reduced the expression levels of the proinflammatory cytokines IL-1β, IL-6, and tumor necrosis factor- (TNF-) α.
Compared to control-treated DCs, FA significantly enhanced the expressions of Notch ligand Delta-like 4 (Dll4), MHC class II, and CD40 molecules by these DCs.
Furthermore, these FA-treated DCs enhanced T-cell proliferation and Th1 cell polarization.
In animal experiments, oral administration of FA reduced the levels of OVA-specific immunoglobulin E (IgE) and IgG1 and enhanced IgG2a antibody production in serum.
It also ameliorated airway hyperresponsiveness and attenuated eosinophilic pulmonary infiltration in dose-dependent manners.
In addition, FA treatment inhibited the production of eotaxin, Th2 cytokines (IL-4, IL-5, and IL-13), and proinflammatory cytokines but promoted the Th1 cytokine interferon- (IFN-) γ production in bronchoalveolar lavage fluid (BALF) and the culture supernatant of spleen cells.
These findings suggest that FA exhibits an antiallergic effect via restoring Th1/Th2 imbalance by modulating DCs function in an asthmatic mouse model.
American Psychological Association (APA)
Lee, Chen-Chen& Wang, Ching-Chiung& Huang, Huei-Mei& Lin, Chu-Lun& Leu, Sy-Jye& Lee, Yueh-Lun. 2015. Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1063454
Modern Language Association (MLA)
Lee, Chen-Chen…[et al.]. Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1063454
American Medical Association (AMA)
Lee, Chen-Chen& Wang, Ching-Chiung& Huang, Huei-Mei& Lin, Chu-Lun& Leu, Sy-Jye& Lee, Yueh-Lun. Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1063454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063454