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Antidiarrhoeal Activity of Musa paradisiaca Sap in Wistar Rats
Joint Authors
Yakubu, Musa Toyin
Nurudeen, Quadri O.
Salimon, Saoban S.
Yakubu, Monsurat O.
Jimoh, Rukayat O.
Akanji, Musbau A.
Oladiji, Adenike T.
Williams, Felicia E.
Nafiu, Mikhail Olugbemiro
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The folkloric claim of Musa paradisiaca sap in the management of diarrhoea is yet to be substantiated or refuted with scientific data.
Therefore, the aim of the current study was to screen the sap of M.
paradisiaca for both its secondary metabolites and antidiarrhoeal activity at 0.25, 0.50, and 1.00 mL in rats.
Secondary metabolites were screened using standard methods while the antidiarrhoeal activity was done by adopting the castor oil-induced diarrhoeal, castor oil-induced enteropooling, and gastrointestinal motility models.
The sap contained flavonoids, phenolics, saponins, alkaloids, tannins, and steroids while cardiac glycosides, anthraquinones, triterpenes, cardenolides, and dienolides were not detected.
In the castor oil-induced diarrhoeal model, the sap significantly ( P < 0.05 ) prolonged the onset time of diarrhoea, decreased the number, fresh weight, and water content of feaces, and increased the inhibition of defecations.
Na+-K+-ATPase activity in the small intestine increased significantly whereas nitric oxide content decreased.
The decreases in the masses and volumes of intestinal fluid by the sap were accompanied by increase in inhibition of intestinal fluid content in the enteropooling model.
The sap decreased the charcoal meal transit in the gastrointestinal motility model.
In all the models, the 1.00 mL of the sap produced changes that compared well with the reference drugs.
Overall, the antidiarrhoeal activity of Musa paradisiaca sap attributed to the presence of alkaloids, phenolics, flavonoids, and/or saponins which may involve, among others, enhancing fluid and electrolyte absorption through de novo synthesis of the sodium potassium ATPase and/or reduced nitric oxide levels.
American Psychological Association (APA)
Yakubu, Musa Toyin& Nurudeen, Quadri O.& Salimon, Saoban S.& Yakubu, Monsurat O.& Jimoh, Rukayat O.& Nafiu, Mikhail Olugbemiro…[et al.]. 2015. Antidiarrhoeal Activity of Musa paradisiaca Sap in Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063459
Modern Language Association (MLA)
Yakubu, Musa Toyin…[et al.]. Antidiarrhoeal Activity of Musa paradisiaca Sap in Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063459
American Medical Association (AMA)
Yakubu, Musa Toyin& Nurudeen, Quadri O.& Salimon, Saoban S.& Yakubu, Monsurat O.& Jimoh, Rukayat O.& Nafiu, Mikhail Olugbemiro…[et al.]. Antidiarrhoeal Activity of Musa paradisiaca Sap in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063459