Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease
Joint Authors
Jia, Jun
Wang, Fang
Sun, Li
Liu, Zhuo
Huang, Xi-yan
Yu, Shu-yang
Zuo, Li-jun
Cao, Chen-jie
Wang, Xiao-min
Zhang, Wei
Zhang, Xiaozhe
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objectives.
To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson’s disease (PD) patients.
Methods.
Fifty PD patients were randomly assigned to drug plus EA (D + EA) group and drug alone (D) group.
Subjects in D + EA group received stimulation in points of bilateral fengfu, fengchi, hegu, and central dazhui.
Participants were evaluated by scales for motor and nonmotor symptoms.
Levels of neuroinflammatory factors and neurotransmitters in serum were detected.
Results.
EA add-on treatment remarkably reduced scores of Unified Parkinson’s Disease Rating Scale (UPDRS) III and its subitems of tremor, rigidity, and bradykinesia and conspicuously decreased UPDRS III scores in patients with bradykinesia-rigidity and mixed types and mild severity.
Depression and sleep disturbances were eased, which were reflected by decreased scores of Hamilton Depression Rating Scale, Pittsburgh Sleep Quality Index, and elevated noradrenaline level.
Effects of EA add-on treatment on motor symptoms and sleep disturbances were superior to drug alone treatment, markedly improving life quality of PD patients.
EA add-on treatment decreased nitric oxide level in serum.
Conclusions.
EA add-on treatment is effective on most motor symptoms and some nonmotor symptoms and is particularly efficacious in PD patients at early stage.
Antineuroinflammation may be a mechanism of EA add-on treatment.
American Psychological Association (APA)
Wang, Fang& Sun, Li& Zhang, Xiaozhe& Jia, Jun& Liu, Zhuo& Huang, Xi-yan…[et al.]. 2015. Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063471
Modern Language Association (MLA)
Wang, Fang…[et al.]. Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1063471
American Medical Association (AMA)
Wang, Fang& Sun, Li& Zhang, Xiaozhe& Jia, Jun& Liu, Zhuo& Huang, Xi-yan…[et al.]. Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1063471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063471