Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats
Joint Authors
Pedrino, Gustavo Rodrigues
Amaral, Nathalia Oda
Lobo de Andrade, Daniela Medeiros
Reis, Carolina de Fátima
Castro, Patrícia Ferreira da Silva
Borges, Leonardo Luiz
Torres, Ieda Maria Sapateiro
Rezende, Stefani Garcia
Gil, Eric de Souza
Cardoso da Conceição, Edemilson
Lavorenti Rocha, Matheus
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study’s aim was to determine the effect of hydroalcoholic extract of M.
cauliflora (HEMC) on vascular tension and blood pressure in rats.
In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium.
Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation.
The treatment with MDL-12,330A (adenylyl cyclase (AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation.
The blockade of muscarinic and β-adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation.
In our in vivo studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement of blood pressure, heart rate, and aortic blood flow.
The intravenous infusion of HEMC produced hypotension and increased aortic blood flow with no changes in heart rate.
These findings showed that HEMC induces endothelium-dependent vascular relaxation and hypotension with no alteration in heart rate.
The NO/sGC/cGMP pathway seems to be the main cellular route involved in the vascular responsiveness.
American Psychological Association (APA)
Lobo de Andrade, Daniela Medeiros& Reis, Carolina de Fátima& Castro, Patrícia Ferreira da Silva& Borges, Leonardo Luiz& Amaral, Nathalia Oda& Torres, Ieda Maria Sapateiro…[et al.]. 2015. Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063474
Modern Language Association (MLA)
Lobo de Andrade, Daniela Medeiros…[et al.]. Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063474
American Medical Association (AMA)
Lobo de Andrade, Daniela Medeiros& Reis, Carolina de Fátima& Castro, Patrícia Ferreira da Silva& Borges, Leonardo Luiz& Amaral, Nathalia Oda& Torres, Ieda Maria Sapateiro…[et al.]. Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063474