Validation of Quantitative HPLC Method for Bacosides in KeenMind
Joint Authors
Dowell, Ashley
Davidson, George
Ghosh, Dilip
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Brahmi (Bacopa monnieri) has been used by Ayurvedic medical practitioners in India for almost 3000 years.
The pharmacological properties of Bacopa monnieri were studied extensively and the activities were attributed mainly due to the presence of characteristic saponins called “bacosides.” Bacosides are complex mixture of structurally closely related compounds, glycosides of either jujubogenin or pseudojujubogenin.
The popularity of herbal medicines and increasing clinical evidence to support associated health claims require standardisation of the phytochemical actives contained in these products.
However, unlike allopathic medicines which typically contain a single active compound, herbal medicines are typically complex mixtures of various phytochemicals.
The assay for bacosides in the British Pharmacopoeia monograph for Bacopa monnieri exemplifies that only a subset of bacosides present are included in the calculation of total bacosides.
These results in calculated bacoside values are significantly lower than those attained for the same material using more inclusive techniques such as UV spectroscopy.
This study illustrates some of the problems encountered when applying chemical analysis for standardisation of herbal medicines, particularly in relation to the new method development and validation of bacosides from KeenMind.
American Psychological Association (APA)
Dowell, Ashley& Davidson, George& Ghosh, Dilip. 2015. Validation of Quantitative HPLC Method for Bacosides in KeenMind. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063475
Modern Language Association (MLA)
Dowell, Ashley…[et al.]. Validation of Quantitative HPLC Method for Bacosides in KeenMind. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063475
American Medical Association (AMA)
Dowell, Ashley& Davidson, George& Ghosh, Dilip. Validation of Quantitative HPLC Method for Bacosides in KeenMind. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063475