Xueshuan Xinmaining Tablet Treats Blood Stasis through Regulating the Expression of F13a1, Car1, and Tbxa2r
Joint Authors
Liu, Jinping
Zhang, Xiaotian
Wang, Fang
Zhang, Chao
Sai, Jingying
Li, Fan
Li, Yang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Xueshuan Xinmaining Tablet (XXT), the Chinese formula, has long been administered in clinical practice for the treatment of cerebral thrombosis and coronary heart disease.
In this study, we aimed to study the effect and the molecular mechanism of activating blood circulation and removing blood stasis.
Rat models of cold coagulation blood stasis were induced with ice-water bath and epinephrine to assess the amelioration of blood stasis by XXT.
Microarray technique was used to identify gene expression from the model and XXT-treated rats.
In addition, Quantitative Real-Time PCR (qPCR) was performed to verify the microarray results.
The results showed that XXT had a good therapeutic effect on blood stasis by reducing the whole blood viscosity (WBV), plasma viscosity (PV), increasing PT, APTT and TT, and by inhibiting platelet aggregation.
Genes were differentially expressed in rats among the model group and the XXT-pretreated groups.
XXT ameliorated blood stasis by regulating the expressions of F13a1, Car1, and Tbxa2r.
American Psychological Association (APA)
Zhang, Xiaotian& Zhang, Chao& Sai, Jingying& Li, Fan& Liu, Jinping& Li, Yang…[et al.]. 2015. Xueshuan Xinmaining Tablet Treats Blood Stasis through Regulating the Expression of F13a1, Car1, and Tbxa2r. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063478
Modern Language Association (MLA)
Zhang, Xiaotian…[et al.]. Xueshuan Xinmaining Tablet Treats Blood Stasis through Regulating the Expression of F13a1, Car1, and Tbxa2r. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063478
American Medical Association (AMA)
Zhang, Xiaotian& Zhang, Chao& Sai, Jingying& Li, Fan& Liu, Jinping& Li, Yang…[et al.]. Xueshuan Xinmaining Tablet Treats Blood Stasis through Regulating the Expression of F13a1, Car1, and Tbxa2r. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063478