![](/images/graphics-bg.png)
The Immunomodulatory Effects of Nidus Vespae on Human Peripheral Blood Immune Cells In Vitro
Joint Authors
Zhu, Ming
Ling, Yang
Qi, Qiufeng
Zhang, Yaping
Bao, Yanqing
Liu, Yongping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Nidus Vespae has been used in traditional Chinese medicine (TCM) to treat various cancers, but the underlying mechanisms were not yet clarified.
This study was to investigate the effect of Nidus Vespae decoction (NVD) on tumor cell viability and immunoregulating functions of human peripheral blood immune cells.
The effects on tumor cell viability, peripheral blood mononuclear cell (PBMC) proliferation activity, and the tumor cell phagocytosis of monocytes were evaluated by cell counting kit-8.
Tumor-killing activity of cytotoxic T lymphocyte (CTL) was analyzed by 51Cr releasing assay.
IgG production of B cells and cytokine (TNF-α and IL-6) secretion of monocytes were determined by ELISA method.
Data showed that NVD has no significant inhibiting effects on gastric cancer cells growth.
Nevertheless, it could obviously promote PBMC proliferation in a time- and concentration-dependent manner.
After treatment with NVD, the CTL cytotoxicity against SGC-7901 was significantly greater than control.
The TNF-α and IL-6 secretion of monocytes and the IgG production of B cells also increased remarkably.
Furthermore, NVD could significantly promote the phagocytosis of monocytes on tumor cells.
These results suggest that NVD appears to have an immunoenhancing effect on immune cells, indicating that Nidus Vespae is worth exploring for immunomodulatory effects in tumor treatment.
American Psychological Association (APA)
Zhu, Ming& Ling, Yang& Qi, Qiufeng& Zhang, Yaping& Bao, Yanqing& Liu, Yongping. 2015. The Immunomodulatory Effects of Nidus Vespae on Human Peripheral Blood Immune Cells In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063480
Modern Language Association (MLA)
Zhu, Ming…[et al.]. The Immunomodulatory Effects of Nidus Vespae on Human Peripheral Blood Immune Cells In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1063480
American Medical Association (AMA)
Zhu, Ming& Ling, Yang& Qi, Qiufeng& Zhang, Yaping& Bao, Yanqing& Liu, Yongping. The Immunomodulatory Effects of Nidus Vespae on Human Peripheral Blood Immune Cells In Vitro. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1063480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063480