The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NOcGMPKATP Signaling Pathway
Joint Authors
Ramos, Márcio Viana
Alencar, Nylane Maria Nunes de
Pinheiro, Rachel Sindeaux Paiva
Figueiredo, Ingrid Samantha Tavares de
Luz, Patrícia Bastos
Freitas, Lyara Barbosa Nogueira
Souza, Tamiris de Fátima Goebel de
Carmo, Luana David do
Marques, Larisse Mota
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Plumeria rubra (Apocynaceae) is frequently used in folk medicine for the treatment of gastrointestinal disorders, hepatitis, and tracheitis, among other infirmities.
The aim of this study was to investigate the gastroprotective potential of a protein fraction isolated from the latex of Plumeria rubra (PrLP) against ethanol-induced gastric lesions and describe the underlying mechanisms.
In a dose-dependent manner, the pretreatment with PrLP prevented ethanol-induced gastric lesions in mice after single intravenous administration.
The gastroprotective mechanism of PrLP was associated with the involvement of prostaglandins and balance of oxidant/antioxidant factors.
Secondarily, the NO/cGMP/KATP pathway and activation of capsaicin-sensitive primary afferents were also demonstrated as part of the mechanism.
This study shows that proteins extracted from the latex of P.
rubra prevent gastric lesions induced in experimental animals.
Also, the results support the use of the plant in folk medicine.
American Psychological Association (APA)
Alencar, Nylane Maria Nunes de & Pinheiro, Rachel Sindeaux Paiva & Figueiredo, Ingrid Samantha Tavares de & Luz, Patrícia Bastos & Freitas, Lyara Barbosa Nogueira & Souza, Tamiris de Fátima Goebel de…[et al.]. 2015. The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NOcGMPKATP Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063482
Modern Language Association (MLA)
Alencar, Nylane Maria Nunes de…[et al.]. The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NOcGMPKATP Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063482
American Medical Association (AMA)
Alencar, Nylane Maria Nunes de & Pinheiro, Rachel Sindeaux Paiva & Figueiredo, Ingrid Samantha Tavares de & Luz, Patrícia Bastos & Freitas, Lyara Barbosa Nogueira & Souza, Tamiris de Fátima Goebel de…[et al.]. The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NOcGMPKATP Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063482
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063482
