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Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens
Joint Authors
Tsai, Meng-Tsz
Chen, Ching-Yi
Pan, Yu-Hui
Wang, Siou-Huei
Mersmann, Harry J.
Ding, Shih-Torng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Betaine is a food component with well-reported hepatoprotection effects.
However, the effects and mechanisms of betaine on liver fibrosis development are still insufficient.
Because metabolic functions of chicken and human liver is similar, we established a chicken model with carbon Tetrachloride- (CCl4-) induced fibrosis for studying antifibrotic effect of betaine in vivo and in vitro.
Two-week-old male chicks were supplemented with betaine (1%, w/v) in drinking water for 2 weeks prior to the initiation of CCl4 treatment (i.p.) until sacrifice.
Primary chicken hepatocytes were treated with CCl4 and betaine to mimic the in vivo supplementation.
The supplementation of betaine significantly alleviated liver fibrosis development along with the inhibition of lipid peroxidation, hepatic inflammation cytokine, and transforming growth factor-β1 expression levels.
These inhibitive effects were also accompanied with the attenuation of hepatic stellate cell activation.
Furthermore, our in vitro studies confirmed that betaine provides antioxidant capacity for attenuating the hepatocyte necrosis by CCl4.
Altogether, our results highlight the antioxidant ability of betaine, which alleviates CCl4-induced fibrogenesis process along with the suppression of hepatic stellate cells activation.
Since betaine is a natural compound without toxicity, we suggest betaine can be used as a potent nutritional or therapeutic factor for reducing liver fibrosis.
American Psychological Association (APA)
Tsai, Meng-Tsz& Chen, Ching-Yi& Pan, Yu-Hui& Wang, Siou-Huei& Mersmann, Harry J.& Ding, Shih-Torng. 2015. Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063500
Modern Language Association (MLA)
Tsai, Meng-Tsz…[et al.]. Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063500
American Medical Association (AMA)
Tsai, Meng-Tsz& Chen, Ching-Yi& Pan, Yu-Hui& Wang, Siou-Huei& Mersmann, Harry J.& Ding, Shih-Torng. Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063500