Yokukansan Increases 5-HT1A Receptors in the Prefrontal Cortex and Enhances 5-HT1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice
Joint Authors
Kase, Yoshio
Ikarashi, Yasushi
Ueki, Toshiyuki
Mizoguchi, Kazushige
Yamaguchi, Takuji
Nishi, Akinori
Hattori, Tomohisa
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The traditional Japanese medicine yokukansan has an anxiolytic effect, which occurs after repeated administration.
In this study, to investigate the underlying mechanisms, we examined the effects of repeated yokukansan administration on serotonin 1A (5-HT1A) receptor density and affinity and its expression at both mRNA and protein levels in the prefrontal cortex (PFC) of socially isolated mice.
Moreover, we examined the effects of yokukansan on a 5-HT1A receptor-mediated behavioral response.
Male mice were subjected to social isolation stress for 6 weeks and simultaneously treated with yokukansan.
Thereafter, the density and affinity of 5-HT1A receptors were analyzed by a receptor-binding assay.
Levels of 5-HT1A receptor protein and mRNA were also measured.
Furthermore, (±)-8-hydroxy-2-(dipropylamino)tetralin hydrobromide (8-OH-DPAT; a 5-HT1A receptor agonist) was injected intraperitoneally, and rearing behavior was examined.
Social isolation stress alone did not affect 5-HT1A receptor density or affinity.
However, yokukansan significantly increased receptor density and decreased affinity concomitant with unchanged protein and mRNA levels.
Yokukansan also enhanced the 8-OH-DPAT-induced decrease in rearing behavior.
These results suggest that yokukansan increases 5-HT1A receptors in the PFC of socially isolated mice and enhances their function, which might underlie its anxiolytic effects.
American Psychological Association (APA)
Ueki, Toshiyuki& Mizoguchi, Kazushige& Yamaguchi, Takuji& Nishi, Akinori& Ikarashi, Yasushi& Hattori, Tomohisa…[et al.]. 2015. Yokukansan Increases 5-HT1A Receptors in the Prefrontal Cortex and Enhances 5-HT1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063502
Modern Language Association (MLA)
Ueki, Toshiyuki…[et al.]. Yokukansan Increases 5-HT1A Receptors in the Prefrontal Cortex and Enhances 5-HT1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063502
American Medical Association (AMA)
Ueki, Toshiyuki& Mizoguchi, Kazushige& Yamaguchi, Takuji& Nishi, Akinori& Ikarashi, Yasushi& Hattori, Tomohisa…[et al.]. Yokukansan Increases 5-HT1A Receptors in the Prefrontal Cortex and Enhances 5-HT1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063502