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Traditional Herbal Formula Banhasasim-tang Exerts Anti-Inflammatory Effects in RAW 264.7 Macrophages and HaCaT Keratinocytes
Joint Authors
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Lim, Hye-Sun
Yoo, Sae-Rom
Jin, Seong Eun
Kim, Yeji
Jeong, Soo-Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Banhasasim-tang (BHSST) is a Korean traditional herbal formula comprising eight medicinal herbs.
The aim of the present study was to investigate the anti-inflammatory effect of BHSST using macrophage and keratinocyte cell lines.
First, we evaluated the effects of BHSST on inflammatory mediator and cytokine production in lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages.
BHSST markedly inhibited the production of nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin- (IL-) 6.
BHSST significantly suppressed the protein expression of toll-like receptor 4 (TLR4) and phosphorylated nuclear factor-kappa B (NF-κB) p65 in RAW 264.7 cells.
Second, we examined whether BHSST influences the production of chemokines and STAT1 phosphorylation in tumor necrosis factor-α/interferon-γ TI-stimulated HaCaT keratinocytes.
BHSST significantly suppressed the production of RANTES/CCL5, TARC/CCL17, MDC/CCL22, and IL-8 in TI-stimulated HaCaT cells.
BHSST also suppressed TI-induced phosphorylation of STAT1 in HaCaT cells.
These results suggest that BHSST may be useful as an anti-inflammatory agent, especially for inflammatory skin diseases.
American Psychological Association (APA)
Jin, Seong Eun& Lim, Hye-Sun& Kim, Yeji& Seo, Chang-Seob& Yoo, Sae-Rom& Shin, Hyeun-Kyoo…[et al.]. 2015. Traditional Herbal Formula Banhasasim-tang Exerts Anti-Inflammatory Effects in RAW 264.7 Macrophages and HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063506
Modern Language Association (MLA)
Jin, Seong Eun…[et al.]. Traditional Herbal Formula Banhasasim-tang Exerts Anti-Inflammatory Effects in RAW 264.7 Macrophages and HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063506
American Medical Association (AMA)
Jin, Seong Eun& Lim, Hye-Sun& Kim, Yeji& Seo, Chang-Seob& Yoo, Sae-Rom& Shin, Hyeun-Kyoo…[et al.]. Traditional Herbal Formula Banhasasim-tang Exerts Anti-Inflammatory Effects in RAW 264.7 Macrophages and HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063506