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Polydatin Inhibits Formation of Macrophage-Derived Foam Cells
Joint Authors
Guo, Gang
Wu, Min
Liu, Meixia
Zhang, Wengao
Liu, Longtao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rhizoma Polygoni Cuspidati, a Chinese herbal medicine, has been widely used in traditional Chinese medicine for a long time.
Polydatin, one of the major active ingredients in Rhizoma Polygoni Cuspidati, has been recently shown to possess extensive cardiovascular pharmacological activities.
In present study, we examined the effects of Polydatin on the formation of peritoneal macrophage-derived foam cells in Apolipoprotein E gene knockout mice (ApoE−/−) and explored the potential underlying mechanisms.
Peritoneal macrophages were collected from ApoE−/− mice and cultured in vitro.
These cells sequentially were divided into four groups: Control group, Model group, Lovastatin group, and Polydatin group.
Our results demonstrated that Polydatin significantly inhibits the formation of foam cells derived from peritoneal macrophages.
Further studies indicated that Polydatin regulates the metabolism of intracellular lipid and possesses anti-inflammatory effects, which may be regulated through the PPAR-γ signaling pathways.
American Psychological Association (APA)
Wu, Min& Liu, Meixia& Guo, Gang& Zhang, Wengao& Liu, Longtao. 2015. Polydatin Inhibits Formation of Macrophage-Derived Foam Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063507
Modern Language Association (MLA)
Wu, Min…[et al.]. Polydatin Inhibits Formation of Macrophage-Derived Foam Cells. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1063507
American Medical Association (AMA)
Wu, Min& Liu, Meixia& Guo, Gang& Zhang, Wengao& Liu, Longtao. Polydatin Inhibits Formation of Macrophage-Derived Foam Cells. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1063507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063507