Resveratrol Protects PC12 Cell against 6-OHDA Damage via CXCR4 Signaling Pathway
Joint Authors
Zhang, Jing
Fan, Wenchuang
Wang, Hui
Bao, Lihua
Li, Guibao
Li, Tao
Song, Shouyang
Li, Hongyu
Hao, Jing
Sun, Jinhao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Resveratrol, herbal nonflavonoid polyphenolic compound naturally derived from grapes, has long been acknowledged to possess extensive biological and pharmacological properties including antioxidant and anti-inflammatory ones and may exert a neuroprotective effect on neuronal damage in neurodegenerative diseases.
However, the underlying molecular mechanisms remain undefined.
In the present study, we intended to investigate the neuroprotective effects of resveratrol against 6-OHDA-induced neurotoxicity of PC12 cells and further explore the possible mechanisms involved.
For this purpose, PC12 cells were exposed to 6-OHDA in the presence of resveratrol (0, 12.5, 25, and 50 μM).
The results showed that resveratrol increased cell viability, alleviated the MMP reduction, and reduced the number of apoptotic cells as measured by MTT assay, JC-1 staining, and Hoechst/PI double staining (all p<0.01).
Immunofluorescent staining and Western blotting revealed that resveratrol averts 6-OHDA induced CXCR4 upregulation (p<0.01).
Our results demonstrated that resveratrol could effectively protect PC12 cells from 6-OHDA-induced oxidative stress and apoptosis via CXCR4 signaling pathway.
American Psychological Association (APA)
Zhang, Jing& Fan, Wenchuang& Wang, Hui& Bao, Lihua& Li, Guibao& Li, Tao…[et al.]. 2015. Resveratrol Protects PC12 Cell against 6-OHDA Damage via CXCR4 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063509
Modern Language Association (MLA)
Zhang, Jing…[et al.]. Resveratrol Protects PC12 Cell against 6-OHDA Damage via CXCR4 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1063509
American Medical Association (AMA)
Zhang, Jing& Fan, Wenchuang& Wang, Hui& Bao, Lihua& Li, Guibao& Li, Tao…[et al.]. Resveratrol Protects PC12 Cell against 6-OHDA Damage via CXCR4 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1063509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063509