Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits
Joint Authors
Zafar, Fatiqa
Jahan, Nazish
Khalil-Ur-Rahman, Nazish
Khan, Ahrar
Akram, Waseem
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs.
The synergetic cardioprotective potential of herbal combination of four plants T.
arjuna (T.A.), P.
nigrum (P.N), C.
grandiflorus (C), and C.
oxyacantha (Cr) was assessed through curative and preventive mode of treatment.
In preventive mode of treatment, the cardiac injury was induced with synthetic catecholamine (salbutamol) to pretreated rabbits with the proposed herbal combination for three weeks.
In curative mode of treatment, cardiotoxicity/oxidative stress was induced in rabbits with salbutamol prior to treating them with plant mixture.
Cardiac marker enzymes, lipids profile, and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals.
Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis.
However, pre- and postadministration of plant mixture appreciably restored the levels of all biomarkers.
Histopathological examination confirmed that the said combination was safer cardioprotective product.
American Psychological Association (APA)
Zafar, Fatiqa& Jahan, Nazish& Khalil-Ur-Rahman, Nazish& Khan, Ahrar& Akram, Waseem. 2015. Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063515
Modern Language Association (MLA)
Zafar, Fatiqa…[et al.]. Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1063515
American Medical Association (AMA)
Zafar, Fatiqa& Jahan, Nazish& Khalil-Ur-Rahman, Nazish& Khan, Ahrar& Akram, Waseem. Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1063515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063515