Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade.
Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively.
Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used herbs can provide robust fundamentals for optimizing CYP and/or P-gp substrate drug-based therapy.
Herein, we review ten popular medicinal and/or dietary herbs as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions.
The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in several in vitro and in vivo animal and human systems.
American Psychological Association (APA)
Cho, Hyun-Jong& Yoon, In-Soo. 2015. Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063528
Modern Language Association (MLA)
Cho, Hyun-Jong& Yoon, In-Soo. Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063528
American Medical Association (AMA)
Cho, Hyun-Jong& Yoon, In-Soo. Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063528