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Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana
Joint Authors
Jeong, Deok
Kim, Ji Hye
Kim, Han Gyung
Yang, Sungjae
Yoon, Deok Hyo
Sung, Nak Yoon
Baek, Kwang-Soo
Lee, Sang Yeol
Lee, Yunmi
Kang, Hyojeung
Song, Changsik
Cho, Jae Han
Lee, Kang-Hyo
Kim, Tae Woong
Cho, Jae Youl
Park, Jae Gwang
Sung, Gi-Ho
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Cordyceps species have been widely used for treating various cancer diseases.
Although the Cordyceps species have been widely known as an alternative anticancer remedy, which compounds are responsible for their anticancer activity is not fully understood.
In this study, therefore, we examined the anticancer activity of 5 isolated compounds derived from the butanol fraction (Cb-BF) of Cordyceps bassiana.
For this purpose, several cancer cell lines such as C6 glioma, MDA-MB-231, and A549 cells were employed and details of anticancer mechanism were further investigated.
Of 5 compounds isolated by activity-guided fractionation from BF of Cb-EE, KTH-13, and 4-isopropyl-2,6-bis(1-phenylethyl)phenol, Cb-BF was found to be the most potent antiproliferative inhibitor of C6 glioma and MDA-MB-231 cell growth.
KTH-13 treatment increased DNA laddering, upregulated the level of Annexin V positive cells, and altered morphological changes of C6 glioma and MDA-MB-231 cells.
In addition, KTH-13 increased the levels of caspase 3, caspase 7, and caspase 9 cleaved forms as well as the protein level of Bax but not Bcl-2.
It was also found that the phosphorylation of AKT and p85/PI3K was also clearly reduced by KTH-13 exposure.
Therefore, our results suggest KTH-13 can act as a potent antiproliferative and apoptosis-inducing component from Cordyceps bassiana, contributing to the anticancer activity of this mushroom.
American Psychological Association (APA)
Kim, Ji Hye& Lee, Yunmi& Sung, Gi-Ho& Kim, Han Gyung& Jeong, Deok& Park, Jae Gwang…[et al.]. 2015. Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063536
Modern Language Association (MLA)
Kim, Ji Hye…[et al.]. Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1063536
American Medical Association (AMA)
Kim, Ji Hye& Lee, Yunmi& Sung, Gi-Ho& Kim, Han Gyung& Jeong, Deok& Park, Jae Gwang…[et al.]. Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1063536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063536