Vitamin E Analogs as Radiation Response Modifiers
Joint Authors
Singh, Pankaj K.
Krishnan, Sunil
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The potentially life-threatening effects of total body ionizing radiation exposure have been known for more than a century.
Despite considerable advances in our understanding of the effects of radiation over the past six decades, efforts to identify effective radiation countermeasures for use in case of a radiological/nuclear emergency have been largely unsuccessful.
Vitamin E is known to have antioxidant properties capable of scavenging free radicals, which have critical roles in radiation injuries.
Tocopherols and tocotrienols, vitamin E analogs together known as tocols, have shown promise as radioprotectors.
Although the pivotal mechanisms of action of tocols have long been thought to be their antioxidant properties and free radical scavenging activities, other alternative mechanisms have been proposed to drive their activity as radioprotectors.
Here we provide a brief overview of the effects of ionizing radiation, the mechanistic mediators of radiation-induced damage, and the need for radiation countermeasures.
We further outline the role for, efficacy of, and mechanisms of action of tocols as radioprotectors, and we compare and contrast their efficacy and mode of action with that of another well-studied chemical radioprotector, amifostine.
American Psychological Association (APA)
Singh, Pankaj K.& Krishnan, Sunil. 2015. Vitamin E Analogs as Radiation Response Modifiers. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1063544
Modern Language Association (MLA)
Singh, Pankaj K.& Krishnan, Sunil. Vitamin E Analogs as Radiation Response Modifiers. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1063544
American Medical Association (AMA)
Singh, Pankaj K.& Krishnan, Sunil. Vitamin E Analogs as Radiation Response Modifiers. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1063544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063544