Litsea japonica Extract Inhibits Aldose Reductase Activity and Hyperglycemia-Induced Lenticular Sorbitol Accumulation in dbdb Mice
Joint Authors
Kim, Chan-Sik
Sohn, Eunjin
Lee, Yun Mi
Jo, Kyuhyung
Kim, Jin Sook
Kim, Junghyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway.
AR-dependent synthesis of excess polyols leads to lens opacification in diabetic cataract.
The purpose of this study is to investigate the protective effect of Litsea japonica extract (LJE) on diabetes-induced lens opacification and its protective mechanism in db/db mice.
Seven-week-old male db/db mice were treated with LJE (100 and 250 mg/kg body weight) once a day orally for 12 weeks.
LJE dose dependently inhibited rat lens aldose reductase activity in vitro (IC50 = 13.53 ± 0.74 µg/mL).
In db/db mice, lens was slightly opacified, and lens fiber cells were swollen and ruptured.
In addition, lenticular sorbitol accumulation was increased in db/db mice.
However, the administration of LJE inhibited these lenticular sorbitol accumulation and lens architectural changes in db/db mice.
Our results suggest that LJE might be beneficial for the treatment of diabetes-induced lens opacification.
The ability of LJE to suppress lenticular sorbitol accumulation may be mediated by the inhibition of AR activity.
American Psychological Association (APA)
Kim, Junghyun& Kim, Chan-Sik& Sohn, Eunjin& Lee, Yun Mi& Jo, Kyuhyung& Kim, Jin Sook. 2015. Litsea japonica Extract Inhibits Aldose Reductase Activity and Hyperglycemia-Induced Lenticular Sorbitol Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063548
Modern Language Association (MLA)
Kim, Junghyun…[et al.]. Litsea japonica Extract Inhibits Aldose Reductase Activity and Hyperglycemia-Induced Lenticular Sorbitol Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1063548
American Medical Association (AMA)
Kim, Junghyun& Kim, Chan-Sik& Sohn, Eunjin& Lee, Yun Mi& Jo, Kyuhyung& Kim, Jin Sook. Litsea japonica Extract Inhibits Aldose Reductase Activity and Hyperglycemia-Induced Lenticular Sorbitol Accumulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1063548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1063548